Browsing Institutt for klinisk medisin by Title

Now showing items 10845-10864 of 10911

  • Whole-exome sequencing in syndromic craniosynostosis increases diagnostic yield and identifies candidate genes in osteogenic signaling pathways 
    Tønne, Elin; Due-Tønnessen, Bernt Johan; Vigeland, Magnus Dehli; Amundsen, Silja Svanstrøm; Ribarska, Teodora Plamenova; Åsten, Pamela; Sheng, Ying; Helseth, Eirik; Gilfillan, Gregor; Mero, Inger-Lise; Heimdal, Ketil Riddervold (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Craniosynostosis (CS) is a common congenital anomaly defined by premature fusion of one or more cranial sutures. Syndromic CS involves additional organ anomalies or neurocognitive deficits and accounts for 25%–30% of the ...
  • Whole-genome characterization of hemolytic uremic syndrome-causing Shiga toxin-producing Escherichia coli in Sweden 
    Hua, Ying; Chromek, Milan; Frykman, Anne; Jernberg, Cecilia; Georgieva, Valya; Hansson, Sverker; Zhang, Ji; Marits, Ann Katrine; Wan, Chengsong; Matussek, Andreas; Bai, Xiangning (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Shiga toxin-producing Escherichia coli, a foodborne bacterial pathogen, has been linked to a broad spectrum of clinical outcomes ranging from asymptomatic carriage to fatal hemolytic uremic syndrome (HUS). Here, we collected ...
  • Whole-genome sequencing of a sporadic primary immunodeficiency cohort 
    Thaventhiran, James; Allen, Hana Lango; Burren, Oliver S; Rae, William; Greene, Daniel; Staples, Emily; Zhang, Zinan; Farmery, James H.R.; Simeoni, Ilenia; Rivers, Elizabeth; Maimaris, Jesmeen; Penkett, Christopher J.; Stephens, Jonathan; Deevi, Sri VV; Sanchis-Juan, Alba; Ellinghaus, Eva; Ellinghaus, David; Jørgensen, Silje Fjellgård; Karlsen, Tom Hemming; Lyons, Paul A; Hurles, Matthew E.; Savic, Sinisa; Burns, Siobhán; Kuijpers, Taco W.; Turro, Ernest; Ouwehand, Willem H; Thrasher, Adrian J; Smith, Kenneth GC; Abbs, Stephen; Adhya, Zoe; Adlard, Julian; Afzal, Maryam; Ahmed, Irshad; Ahmed, Munaza; Ahmed, Saeed; Aitman, Timothy J.; Alachkar, Hana; Alamelu, Jayanthi; Alikhan, Raza; Allen, Carl E.; Allen, Louise; Allsup, David J.; Alvi, Arif; Ambegaonkar, Gautam; Anantharachagan, Ariharan; Ancliff, Philip; Anderson, Julie R.; Antrobus, Richard; Armstrong, Ruth; Arno, Gavin (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. Although the most severe forms of PID ...
  • Whose decision? Negotiating epistemic and deontic rights in medical treatment decisions 
    Dalby, Anne Marie Landmark; Gulbrandsen, Pål; Svennevig, Jan (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2015)
    Shared decision making has become an ideal in contemporary clinical practice, and guidelines recommend exploring patients’ preferences and providing them with options so they can make informed decisions. This paper examines ...
  • Why Do Those With Long-Term Substance Use Disorders Stop Abusing Substances: A Qualitative Study 
    Pettersen, Henning; Landheim, Anne; Skeie, Ivar; Biong, Stian; Brodahl, Morten; Benson, Victoria; Davidson, Larry (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Although a significant proportion of adults recover from substance use disorders (SUDs), little is known about how they reach this turning point or why they stop using. The purpose of the study was to explore the factors ...
  • Why does Russia have such high cardiovascular mortality rates? Comparisons of blood-based biomarkers with Norway implicate non-ischaemic cardiac damage. 
    Iakunchykova, Olena; Averina, Maria; Wilsgaard, Tom; Watkins, Hugh; Malyutina, Sofia; Ragino, Yulia; Keogh, Ruth; Kudryavtsev, Alexander V; Govorun, Vadim; Cook, Sarah Anne; Schirmer, Henrik; Eggen, Anne Elise; Hopstock, Laila Arnesdatter; Leon, David Adrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Russia has one of the highest rates of mortality from cardiovascular disease (CVD). At age 35–69 years, they are eight times higher than in neighbouring Norway. Comparing profiles of blood-based CVD biomarkers ...
  • Why Not Dipyridamole: a Review of Current Guidelines and Re-evaluation of Utility in the Modern Era 
    Allahham, Mahmoud; Lerman, A.; Atar, Dan; Birnbaum, Yochai (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
    Dipyridamole is an old anti-platelet and coronary vasodilator agent that inhibits platelet phosphodiesterase and increases interstitial adenosine levels. Its use in coronary artery disease (CAD) has fallen out of practice ...
  • Why the Norwegian 2021 guideline for basic life support are different 
    Bjørshol, Conrad Arnfinn; Nordseth, Trond; Kramer-Johansen, Jo (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
  • Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma 
    Bjørklund, Sunniva Maria Stordal; Panda, Anshuman; Kumar, Surendra; Seiler, Michael; Robinson, Doug; Gheeya, Jinesh; Yao, Ming; Grenaker, Grethe Irene; Toppmeyer, Deborah; Riis, Margit; Naume, Bjørn; Børresen-Dale, Anne-Lise; Kristensen, Vessela N.; Ganesan, Shridar; Bhanot, Gyan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Cancer cells can have different patterns of exon usage of individual genes when compared to normal tissue, suggesting that alternative splicing may play a role in shaping the tumor phenotype. The discovery and identification ...
  • Widespread Changes in White Matter Microstructure After a Day of Waking and Sleep Deprivation 
    Elvsåshagen, Torbjørn; Norbom, Linn Christin Bonaventure; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H.; Bjørnerud, Atle; Malt, Ulrik Fredrik; Groote, Inge Rasmus; Westlye, Lars Tjelta (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Elucidating the neurobiological effects of sleep and waking remains an important goal of the neurosciences. Recently, animal studies indicated that sleep is important for cell membrane and myelin maintenance in ...
  • Widespread distribution of lymphatic vessels in human dura mater remote from sinus veins 
    Vera Quesada, Cesar Luis; Shreyas, Rao; Torp, Reidun; Eide, Per Kristian (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background and purpose: Previous experimental studies have shown that meningeal lymphatic vessels are located primarily along the walls of the dural sinus veins. Whether they are more widespread throughout human dura mater ...
  • Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives 
    Juvodden, Hilde Therese; Alnæs, Dag; Lund, Martina Jonette; Agartz, Ingrid; Andreassen, Ole Andreas; Dietrichs, Espen; Thorsby, Per Medbøe; Westlye, Lars Tjelta; Knudsen, Stine (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Study Objectives To assess white matter involvement in H1N1-vaccinated hypocretin deficient patients with narcolepsy type 1 (NT1) compared with first-degree relatives (a potential risk group) and healthy controls. Me ...
  • Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group 
    Kelly, S; Jahanshad, Neda; Zalesky, A; P, Kochunov; Agartz, Ingrid; Alloza, C; Andreassen, Ole Andreas; Arango, C; Banaj, Nerisa; Bouix, S; Bousman, CA; Brouwer, RM; Bruggemann, J; Bustillo, Juan R; Cahn, Wiepke; Calhoun, Vince; Cannon, Dara M; Carr, Vaughan J.; Catts, Stanley V.; Chen, J; Chen, JX; Chen, X; Chiapponi, C; Cho, KK; Ciullo, Valentina; Corvin, A; Crespo-Facorro, Benedicto; Cropley, V; De Rossi, Pietro; Diaz-Caneja, CM; Dickie, EW; Ehrlich, S; Fan, FM; Faskowitz, Joshua; Fatouros-Bergman, Helena; Flyckt, Lena; Ford, JM; Fouche, JP; Fukunaga, Masaki; Gill, M; Glahn, DC; Gollub, Randy L; Goudzwaard, ED; Guo, H; Gur, RE; Gur, RC; Gurholt, Tiril Pedersen; Hashimoto, Ryota; Hatton, SN; Henskens, FA; Hibar, DP; Hickie, IB; Hong, LE; Horacek, Jan; Howells, FM; Hulshoff Pol, Hilleke E; Hyde, CL; Isaev, D; Jablensky, Assen; Jansen, PR; Janssen, J; Jönsson, Erik Gunnar; Jung, LA; Kahn, RS; Kikinis, Z; Liu, K; Klauser, Paul; Knöchel, C; Kubicki, M; Lagopoulos, Jim; Langen, C; Lawrie, Stephen M; Lenroot, R; Lim, KO; Lopez-Jaramillo, Carlos; Lyall, A; Magnotta, V; Mandl, RCW; Mathalon, DH; McCarley, RW; McCarthy-Jones, Simon; McDonald, C; McEwen, S; McIntosh, A; Melicher, T; Mesholam-Gately, RI; Michie, PT; Mowry, Bryan J.; Mueller, BA; Newell, DT; O'donnell, P; Oertel-Knöchel, V; Oestreich, L; Paciga, SA; Pantelis, Christos; Pasternak, O; Pearlson, Godfrey D; Pellicano, GR; Pereira, A; Pineda Zapata, J; Piras, Fabrizio; Potkin, SG; Preda, Adrian; Rasser, PE; Roalf, DR; Roiz, R; Roos, A; Rotenberg, D; Satterthwaite, TD; Savadjiev, P; Schall, Ulrich; Scott, RJ; Seal, ML; Seidman, LJ; Shannon Weickert, C; Whelan, CD; Shenton, ME; Kwon, JS; Spalletta, Gianfranco; Spaniel, F; Sprooten, Emma; Stäblein, M; Stein, DJ; Sundram, S; Tan, Y; Tan, S; Tang, S; Temmingh, HS; Westlye, Lars Tjelta; Tønnesen, Siren; Tordesillas-Gutierrez, Diana; Doan, Nhat Trung; Vaidya, Jatin G.; Van Haren, NEM; Vargas, CD; Vecchio, D; Velakoulis, D; Voineskos, Aristotle N.; Voyvodic, JQ; Wang, Z; Wan, P; Wei, D; Weickert, TW; Whalley, Heather Clare; White, T; Whitford, TJ; Wojcik, JD; XIANG, HUA; Xie, Z; Yamamori, Hidenaga; Yang, F; Yao, N; Zhang, G.; Zhao, J; Van Erp, Theo G M; Turner, J; Thompson, PM; Donohoe, Gary (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across ...
  • Will patient feedback improve Quality and Outcome in Psychotherapy? Implementation and validation of the online feedback system OQ®-Analyst in Norway: A multi-site RCT study 
    Amble, Ingunn Agathe (Doctoral thesis / Doktoravhandling, 2016)
    This thesis deals with the aspects of monitoring psychotherapy in ordinary psychiatric settings in Norway with the goal of improving the quality of mental health services. The research resulted in three published papers. ...
  • Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: A proof of concept for multivariate endophenotypes 
    Fan, Chun Chieh; Schork, Andrew J.; Brown, Timothy T.; Spencer, Barbara E.; Akshoomoff, Natacha; Chen, Chi-Hua; Kuperman, Joshua M.; Hagler, Donald J.; Steen, Vidar Martin; Le Hellard, Stephanie; Håberg, Asta; Espeseth, Thomas; Andreassen, Ole Andreas; Dale, Anders; Jernigan, Terry L.; Halgren, Eric (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Despite great interest in using magnetic resonance imaging (MRI) for studying the effects of genes on brain structure in humans, current approaches have focused almost entirely on predefined regions of interest and had ...
  • WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP 
    Lu, Guang; Tan, Hayden Weng Siong; Schmauck-Medina, Tomás Alejandro; Wang, Liming; Chen, Jiaqing; Cho, Yik-Lam; Chen, Kelie; Zhang, Jing-Zi; He, Weifeng; Wu, Yihua; Xia, Dajing; Zhou, Jing; Fang, Fei; Fang, Lei; Liu, Wei; Shen, Han-Ming (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    The mammalian Atg18 ortholog WIPI2 is a key regulator of LC3 lipidation to promote autophagosome biogenesis during nonselective macroautophagy, while its functions in selective autophagy such as mitophagy remain largely ...
  • Wireless motility capsule compared with scintigraphy in the assessment of diabetic gastroparesis 
    Sangnes, Dag André; Softeland, Eirik; Bekkelund, Mattis; Frey, Jakub; Biermann, Martin; Gilja, Odd Helge; Dimcevski, Georg Gjorgji (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background Gastroparesis is a potentially severe late complication of diabetes mellitus. Today, delayed gastric emptying (GE) is mandatory for establishing the diagnosis. In this study, we compared wireless motility ...
  • Wireless patient monitoring and Efficacy Safety Score in postoperative treatment at the ward: evaluation of time consumption and usability 
    Skraastad, Erlend Johan; Borchgrevink, Petter Chr.; Opøyen, Lillian Asbøll; Ræder, Johan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
    Abstract To evaluate objective time consumption and how nurses perceived introducing wireless patient monitoring (WPM) and a validated score on patient quality and safety, the Efficacy Safety Score (ESS), at a mixed surgery ...
  • Within-network connectivity in the salience network after attention bias modification training in residual depression: Report from a preregistered clinical trial 
    Hilland, Eva; Landrø, Nils Inge; Harmer, Catherine; Maglanoc, Luigi Angelo; Jonassen, Rune (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Alterations in resting state networks (RSNs) are associated with emotional- and attentional control difficulties in depressed individuals. Attentional bias modification (ABM) training may lead to more adaptive emotional ...
  • Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects 
    Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Hansen, Ailin Falkmo; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; Lind, Penelope A.; Palviainen, Teemu; van der Zee, Matthijs D.; Cheesman, Rosa Catherine Gillespie; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; Ratliff, Scott M.; Bielak, Lawrence F.; Nygaard, Marianne; Giannelis, Alexandros; Willoughby, Emily A.; Reynolds, Chandra A.; Balbona, Jared V.; Andreassen, Ole; Ask, Helga; Baras, Aris; Bauer, Christopher R.; Boomsma, Dorret I.; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; Corfield, Elizabeth Claire; Dahm, Christina C.; Dokuru, Deepika R.; Evans, Luke M.; de Geus, Eco J. C.; Giddaluru, Sudheer; Gordon, Scott D.; Harden, K. Paige; Hill, W. David; Hughes, Amanda; Kerr, Shona M.; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; Lawlor, Deborah A.; Li, Liming; Lin, Kuang; Magnus, Per Minor; Magnusson, Patrik K. E.; Mallard, Travis T.; Martikainen, Pekka; Mills, Melinda C.; Njølstad, Pål Rasmus; Overton, John D.; Pedersen, Nancy L.; Porteous, David J.; Reid, Jeffrey; Silventoinen, Karri; Southey, Melissa C.; Stoltenberg, Camilla; Tucker-Drob, Elliot M.; Wright, Margaret J.; Kweon, Hyeokmoon; Koellinger, Philipp D.; Benjamin, Daniel J.; Turley, Patrick; Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; Martin, Nicholas G.; Oskarsson, Sven; Justice, Anne E.; Millwood, Iona Y.; Hveem, Kristian; Naess, Øyvind; Willer, Cristen J.; Åsvold, Bjørn Olav; Kaprio, Jaakko; Medland, Sarah E.; Walters, Robin G.; Evans, David M.; Smith, George Davey; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; Davies, Neil Martin; Hewitt, John K.; Keller, Matthew C.; Stallings, Michael C.; Lee, James J.; Christensen, Kaare; Kardia, Sharon L. R.; Peyser, Patricia A.; Smith, Jennifer A.; Wilson, James F.; Hopper, John L.; Hägg, Sara; Spector, Tim D.; Pingault, Jean-Baptiste; Næss, Øyvind Erik; Davey Smith, George; Brumpton, Ben Michael (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives ...