Browsing CRIStin høstingsarkiv by Author "O'Connell, Kevin Sean"

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  • Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology 
    van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin Sean; Bettella, Francesco; Djurovic, Srdjan; Wolfers, Thomas; Alnæs, Dag; Agartz, Ingrid; Smeland, Olav Bjerkehagen; Melle, Ingrid; Sánchez, Jennifer Monereo; Linden, David E.J.; Dale, Anders; Westlye, Lars Tjelta; Andreassen, Ole; Frei, Oleksandr; Kaufmann, Tobias (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Schizophrenia is a complex polygenic disorder with subtle, distributed abnormalities in brain morphology. There are indications of shared genetic architecture between schizophrenia and brain measures despite ...
  • Characterisation of age and polarity at onset in bipolar disorder 
    Kalman, Janos L.; Loohuis, Loes M. Olde; Vreeker, Annabel; McQuillin, Andrew; Stahl, Eli A.; Ruderfer, Douglas; Grigoroiu-Serbanescu, Maria; Panagiotaropoulou, Georgia; Ripke, Stephan; Bigdeli, Tim B.; Stein, Frederike; Meller, Tina; Meinert, Susanne; Pelin, Helena; Streit, Fabian; Papiol, Sergi; Adams, Mark J.; Adolfsson, Rolf; Adorjan, Kristina; Agartz, Ingrid; Aminoff, Sofie Ragnhild; Anderson-Schmidt, Heike; Andreassen, Ole Andreas; Ardau, Raffaella; Aubry, Jean-Michel; Balaban, Ceylan; Djurovic, Srdjan; Lagerberg, Trine Vik; Melle, Ingrid; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening ...
  • Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking 
    Hindley, Guy Frederick Lanyon; Bahrami, Shahram; Steen, Nils Eiel; O'Connell, Kevin Sean; Frei, Oleksandr; Shadrin, Alexey; Bettella, Francesco; Rødevand, Linn; Fan, Chun-Chieh; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and ...
  • Characterizing the Genetic Overlap Between Psychiatric Disorders and Sleep-Related Phenotypes 
    O'Connell, Kevin Sean; Frei, Oleksandr; Bahrami, Shahram; Smeland, Olav Bjerkehagen; Bettella, Francesco; Cheng, Weiqiu; Chu, Yunhan; Hindley, Guy; Lin, Aihua; Shadrin, Alexey; Barrett, Elizabeth Ann; Lagerberg, Trine Vik; Steen, Nils Eiel; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background A range of sleep disturbances are commonly experienced by patients with psychiatric disorders, and genome-wide genetic analyses have shown some significant genetic correlations between these traits. Here, we ...
  • Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders 
    Hindley, Guy; Drange, Ole Kristian; Lin, Aihua; Kutrolli, Gleda; Shadrin, Alexey; Parker, Nadine; O'Connell, Kevin Sean; Rødevand, Linn; Cheng, Weiqiu; Bahrami, Shahram; Karadag, Naz; Holen, Børge; Jaholkowski, Piotr Pawel; Woldeyohannes, Markos Tesfaye; Djurovic, Srdjan; Dale, Anders M.; Frei, Oleksandr; Ueland, Thor; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic liability to elevated CRP on schizophrenia risk and a causative ...
  • Developmental manifestations of polygenic risk for bipolar disorder from infancy to middle childhood 
    Askeland, Ragna Bugge; Hannigan, Laurie John; O'Connell, Kevin Sean; Corfield, Elizabeth Claire; Frei, Oleksandr; Thapar, Anita; Smith, George Davey; Reichborn-Kjennerud, Ted; Andreassen, Ole; Ask, Helga; Havdahl, Alexandra (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention ...
  • Distributed Genetic Effects of the Corpus Callosum Subregions Suggest Links to Neuropsychiatric Disorders and Related Traits 
    Campbell, Megan L.; Dalvie, Shareefa; Shadrin, Alexey; van der Meer, Dennis; O'Connell, Kevin Sean; Frei, Oleksandr; Andreassen, Ole; Stein, Dan J.; Rokicki, Jaroslav (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background: The corpus callosum (CC) is a brain structure with a high heritability and potential role in psychiatric disorders. However, the genetic architecture of the CC and the genetic link with psychiatric disorders ...
  • Dose-dependent transcriptional effects of lithium and adverse effect burden in a psychiatric cohort 
    Krull, Florian; Akkouh, Ibrahim Ahmed; Hughes, Timothy; Bettella, Francesco; Athanasiu, Lavinia; Smeland, Olav Bjerkehagen; O'Connell, Kevin Sean; Brattbakk, Hans-Richard; Steen, Vidar Martin; Steen, Nils Eiel; Djurovic, Srdjan; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Lithium is the first-line treatment for bipolar disorder (BD), but there is a large variation in response rate and adverse effects. Although the molecular effects of lithium have been studied extensively, the specific ...
  • Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo 
    Smith, Robert Løvsletten; Wollmann, Birgit Malene Tovik; Kausberg, Marianne; Mæland, Sondre; Tveito, Marit; O'Connell, Kevin Sean; Molden, Espen; Kringen, Marianne K. (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2022)
    Background: Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of CLZ in vivo is ...
  • Genetic contributions to bipolar disorder: Current status and future directions 
    O'Connell, Kevin Sean; Coombes, Brandon J. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50 million people worldwide. Our understanding of the genetic etiology of BD has greatly increased in recent years with ...
  • Genetic Overlap Between Alzheimer’s Disease and Depression Mapped Onto the Brain 
    Monereo-Sánchez, Jennifer; Schram, Miranda T.; Frei, Oleksandr; O'Connell, Kevin Sean; Shadrin, Alexey; Smeland, Olav Bjerkehagen; Westlye, Lars Tjelta; Andreassen, Ole; Kaufmann, Tobias; Linden, David E. J.; van der Meer, Dennis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background: Alzheimer’s disease (AD) and depression are debilitating brain disorders that are often comorbid. Shared brain mechanisms have been implicated, yet findings are inconsistent, reflecting the complexity of the ...
  • Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts 
    Parker, Nadine; Cheng, Weiqiu; Hindley, Guy; O'Connell, Kevin Sean; Karthikeyan, Sandeep; Holen, Børge; Shadrin, Alexey; Rahman, Zillur; Karadag, Naz; Bahrami, Shahram; Lin, Aihua; Steen, Nils Eiel; Ueland, Thor; Aukrust, Pål; Djurovic, Srdjan; Dale, Anders; Smeland, Olav Bjerkehagen; Frei, Oleksandr; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. ...
  • Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression 
    Holen, Børge; Shadrin, Alexey; Icick, Romain; Filiz, Tahir Tekin; Hindley, Guy Frederick Lanyon; Rødevand, Linn; O'Connell, Kevin Sean; Hagen, Espen; Frei, Oleksandr; Bahrami, Shahram; Cheng, Weiqiu; Parker, Nadine; Woldeyohannes, Markos Tesfaye; Jaholkowski, Piotr Pawel; Karadag, Naz; Dale, Anders M; Djurovic, Srdjan; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Opioid use disorder (OUD) and mental disorders are often comorbid, with increased morbidity and mortality. The causes underlying this relationship are poorly understood. Although these conditions are highly ...
  • Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability 
    Holen, Børge; Kutrolli, Gleda; Shadrin, Alexey; Icick, Romain; Hindley, Guy; Rødevand, Linn; O'Connell, Kevin Sean; Frei, Oleksandr; Parker, Nadine; Tesfaye, Markos; Deak, Joseph D.; Jaholkowski, Piotr Pawel; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole; Smeland, Olav Bjerkehagen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Opioid use disorder (OUD), a serious health burden worldwide, is associated with lower cognitive function. Recent studies have demonstrated a negative genetic correlation between OUD and general cognitive ability ...
  • Genome-wide analysis of anorexia nervosa and major psychiatric disorders and related traits reveals genetic overlap and identifies novel risk loci for anorexia nervosa 
    Bang, Lasse; Bahrami, Shahram; Hindley, Guy; Smeland, Olav Bjerkehagen; Rødevand, Linn; Jaholkowski, Piotr Pawel; Shadrin, Alexey; O'Connell, Kevin Sean; Frei, Oleksandr; Lin, Aihua; Rahman, Zillur; Cheng, Weiqiu; Parker, Nadine; Fan, Chun C.; Dale, Anders M.; Djurovic, Srdjan; Bulik, Cynthia M.; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric ...
  • Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci 
    Wiström, Erik David; O'Connell, Kevin Sean; Karadag, Naz; Bahrami, Shahram; Hindley, Guy Frederick Lanyon; Lin, Aihua; Cheng, Weiqiu; Steen, Nils Eiel; Shadrin, Alexey; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Andreassen, Ole A.; Smeland, Olav Bjerkehagen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background and aim Schizophrenia (SCZ) and bipolar disorder (BD) have a high comorbidity of alcohol use disorder (AUD), and both comorbid AUD and excessive alcohol consumption (AC) have been linked to greater illness ...
  • Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci 
    Jaholkowski, Piotr Pawel; Hindley, Guy; Shadrin, Alexey; Tesfaye, Markos; Bahrami, Shahram; Nerhus, Mari; Rahman, Zillur; O'Connell, Kevin Sean; Holen, Børge; Parker, Nadine; Cheng, Weiqiu; Lin, Aihua; Rødevand, Linn; Karadag, Naz; Frei, Oleksandr; Djurovic, Srdjan; Dale, Anders M.; Smeland, Olav Bjerkehagen; Andreassen, Ole (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. ...
  • Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores 
    Kappel, Djenifer B.; Legge, Sophie E.; Hubbard, Leon; Willcocks, Isabella R.; O'Connell, Kevin Sean; Smith, Robert Løvsletten; Molden, Espen; Andreassen, Ole; King, Adrian; Jansen, John; Helthuis, Marinka; Owen, Michael J.; O'Donovan, Michael C.; Walters, James T.R.; Pardiñas, Antonio F. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Treatment-resistant schizophrenia affects approximately 30% of individuals with the disorder. Clozapine is the medication of choice in treatment-resistant schizophrenia, but optimizing administration and dose ...
  • Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits 
    Lenk, Hasan Çağın; Smith, Robert Løvsletten; O'Connell, Kevin Sean; Jukić, Marin M.; Kringen, Marianne K.; Andreassen, Ole; Ingelman-Sundberg, Magnus; Molden, Espen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Clinical response of clozapine is closely associated with serum concentration. Although tobacco smoking is the key environmental factor underlying interindividual variability in clozapine metabolism, recent genome-wide ...
  • Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation 
    Szabo, Attila; O'Connell, Kevin Sean; Ueland, Thor; Sheikh, Mashhood Ahmed; Agartz, Ingrid; Andreou, Dimitrios; Aukrust, Pål; Boye, Birgitte; Bøen, Erlend; Drange, Ole Kristian; Elvsåshagen, Torbjørn; Engh, John; Hope, Sigrun; Høegh, Margrethe Collier; Joa, Inge; Johnsen, Erik; Kroken, Rune Andreas; Lagerberg, Trine Vik; Lekva, Tove; Malt, Ulrik Fredrik; Melle, Ingrid; Morken, Gunnar; Nærland, Terje; Steen, Vidar Martin; Sørensen, Kjetil; Wedervang-Resell, Kirsten; Weibell, Melissa Anne Elin Authen; Westlye, Lars Tjelta; Steen, Nils Eiel; Andreassen, Ole; Djurovic, Srdjan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their ...