Browsing CRIStin høstingsarkiv by Author "O'Connell, Kevin"

Now showing items 1-7 of 7

  • Complement C4 prevents viral infection through capsid inactivation 
    Bottermann, Maria; Foss, Stian; Caddy, Sarah L.; Clift, Dean; van Tienen, Laurens M.; Vaysburd, Marina; Cruickshank, James Kennedy; O'Connell, Kevin; Clark, Jessica; Mayes, Keith; Higginson, Katie; Lode, Heidrun Elisabeth; McAdam, Martin Berner; Sandlie, Inger; Andersen, Jan Terje; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering ...
  • Discovery of shared genomic loci using the conditional false discovery rate approach 
    Smeland, Olav Bjerkehagen; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Fan, Chun Chieh; Bahrami, Shahram; Holland, Dominic; Djurovic, Srdjan; Thompson, Wesley Kurt; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    In recent years, genome-wide association study (GWAS) sample sizes have become larger, the statistical power has improved and thousands of trait-associated variants have been uncovered, offering new insights into the genetic ...
  • Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence 
    Smeland, Olav Bjerkehagen; Bahrami, Shahram; Frei, Oleksandr; Shadrin, Alexey A.; O'Connell, Kevin; Savage, Jeanne E.; Watanabe, Kyoko; Krull, Florian; Bettella, Francesco; Steen, Nils Eiel; Ueland, Torill; Posthuma, Danielle; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of functional outcome. Despite this, the etiology of the cognitive ...
  • Intracellular neutralisation of rotavirus by VP6-specific IgG 
    Caddy, Sarah L.; Vaysburd, Marina; Wing, Mark; Foss, Stian; Andersen, Jan Terje; O'Connell, Kevin; Mayes, Keith; Higginson, Katie; Iturriza-Gómara, Miren; Desselberger, Ulrich; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are particularly abundant, and as VP6 ...
  • Phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories revealed by AI-MiXeR 
    Shadrin, Alexey A.; Frei, Oleksandr; Smeland, Olav Bjerkehagen; Bettella, Francesco; O'Connell, Kevin; Gani, Osman; Bahrami, Shahram; Uggen, Tea Kristiane Espeland; Djurovic, Srdjan; Holland, Dominic; Andreassen, Ole; Dale, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Motivation Determining the relative contributions of functional genetic categories is fundamental to understanding the genetic etiology of complex human traits and diseases. Here, ...
  • Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms 
    Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel; Andreassen, Ole Andreas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Abstract Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the ...
  • Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity 
    Caddy, Sarah L.; Vaysburd, Marina; Papa, Guido; Wing, Mark; O'Connell, Kevin; Stoycheva, Diana; Foss, Stian; Andersen, Jan Terje; Oxenius, Annette; James, Leo C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Nucleoprotein (N) is an immunodominant antigen in many enveloped virus infections. While the diagnostic value of anti‐N antibodies is clear, their role in immunity is not. This is because while they are non‐neutralising, ...