Browsing Farmasøytisk institutt by Author "Lund, Jenny"

Now showing items 1-14 of 14

  • A medium-chain fatty acid analogue prevents hepatosteatosis and decreases inflammatory lipid metabolites in a murine model of parenteral nutrition-induced hepatosteatosis 
    Cho, Bennet S.; Fligor, Scott C.; Fell, Gillian L.; Secor, Jordan D.; Tsikis, Savas T.; Pan, Amy; Yu, Lumeng J.; Ko, Victoria H.; Dao, Duy T.; Anez-Bustillos, Lorenzo; Hirsch, Thomas I.; Lund, Jenny; Rustan, Arild Christian; Fraser, David A.; Gura, Kathleen M.; Puder, Mark (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Parenteral (intravenous) nutrition is lifesaving for patients with intestinal failure, but long-term use of parenteral nutrition often leads to liver disease. SEFA-6179 is a synthetic medium-chain fatty acid ...
  • Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism 
    Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen; Thoresen, G. Hege (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Background and aims Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in vitro metabolic adaptations by studying ...
  • Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects 
    Lund, Jenny; Tangen, Daniel S.; Wiig, Håvard; Stadheim, Hans Kristian; Siw, Anette Helle; Birk, Jesper B.; Ingemann-Hansen, Thorsten; Rustan, Arild; Thoresen, G. Hege; Wojtaszewski, Jørgen F.P.; Kase, Eili Tranheim; Jensen, Jørgen (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2017)
    We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to investigate glucose metabolism in biopsies and myotubes isolated ...
  • Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects 
    Lund, Jenny; Helle, Siw A.; Li, Yuchuan; Løvsletten, Nils Gunnar; Stadheim, Hans Kristian; Jensen, Jørgen; Kase, Eili Tranheim; Thoresen, G. Hege; Rustan, Arild (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    In this study we compared fatty acid (FA) metabolism in myotubes established from athletic and sedentary young subjects. Six healthy sedentary (maximal oxygen uptake (VO2max)≤ 46 ml/kg/min) and six healthy athletic ...
  • Increased glycolysis and higher lactate production in hyperglycemic myotubes 
    Lund, Jenny; Ouwens, DM; Wettergreen, Marianne; Bakke, Siril Skaret; Thoresen, G. Hege; Aas, Vigdis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Previous studies have shown that chronic hyperglycemia impairs glucose and fatty acid oxidation in cultured human myotubes. To further study the hyperglycemia-induced suppression of oxidation, lactate oxidation, mitochondrial ...
  • Knockdown of sarcolipin (SLN) impairs substrate utilization in human skeletal muscle cells 
    Mengeste, Abel Mulu; Katare, Parmeshwar Bajirao; Dalmao Fernandez, Andrea; Lund, Jenny; Bakke, Hege Gilbø; Baker, David; Bartesaghi, Stefano; Peng, Xiao-Rong; Rustan, Arild Christian; Thoresen, G. Hege; Kase, Eili Tranheim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Background Recent studies have highlighted that uncoupling of sarco-/endoplasmic reticulum Ca 2+ -ATPase (SERCA) by sarcolipin (SLN) increases ATP consumption and contributes to heat liberation. ...
  • Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation 
    Feng, Yuan Zeng; Lund, Jenny; Li, Yuchuan; Knabenes, Irlin K; Bakke, Siril Skaret; Kase, Eili Tranheim; Lee, Yun K; Kimmel, Alan R; Thoresen, G. Hege; Rustan, Arild; Dalen, Knut Tomas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show ...
  • Pancreatic Cancer Cell-Conditioned, Human-Derived Primary Myotubes Display Increased Leucine Turnover, Increased Lipid Accumulation, and Reduced Glucose Uptake 
    Krapf, Solveig; Lund, Jenny; Saqib, Awais Ur Rehman; Bakke, Hege Gilbø; Rustan, Arild Christian; Thoresen, G. Hege; Kase, Eili Tranheim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Metabolic alterations occurring in cancer cells have been seen to also occur in other tissues than cancerous tissue. For instance, cachexia, peripheral insulin resistance, or both are commonly seen in patients with cancer. ...
  • Regulation of energy metabolism in cultured skeletal muscle cells: Effects of exercise, donor differences and perilipin 2. Studies in human and mouse myotubes 
    Lund, Jenny (Doctoral thesis / Doktoravhandling, 2017)
    Exercise can prevent and treat metabolic diseases. This thesis aimed to study energy metabolism in cultured human myotubes from subjects with different metabolic profile and training status, and to study effects of an in ...
  • SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation 
    Krapf, Solveig; Lund, Jenny; Bakke, Hege Gilbø; Nyman, Tuula Anneli; Bartesaghi, Stefano; Peng, Xiao-Rong; Rustan, Arild Christian; Thoresen, G. Hege; Kase, Eili Tranheim (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Adipose tissue is one of the main regulative sites for energy metabolism. Excess lipid storage and expansion of white adipose tissue (WAT) is the primary contributor to obesity, a strong predisposing factor for development ...
  • Substrate oxidation in primary human skeletal muscle cells is influenced by donor age 
    Aas, Vigdis; Thoresen, G. Hege; Rustan, Arild; Lund, Jenny (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Primary human myotubes represent an alternative system to intact skeletal muscle for the study of human diseases related to changes in muscle energy metabolism. This work aimed to study if fatty acid and glucose ...
  • The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background 
    Irshad, Zehra; Lund, Jenny; Sillars, Anne; Løvsletten, Nils Gunnar; Gharanei, Seley; Salt, Ian P.; Freeman, Dilys J.; Gill, Jason M. R.; Thoresen, G. Hege; Rustan, Arild Christian; Zammit, Victor A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Abstract The roles of DGAT1 and DGAT2 in lipid metabolism and insulin responsiveness of human skeletal muscle were studied using cryosections and myotubes prepared from muscle biopsies from control, athlete, and impaired ...
  • Utilization of lactic acid in human myotubes and interplay with glucose and fatty acid metabolism 
    Lund, Jenny; Aas, Vigdis; Tingstad, Ragna Husby; Van Hees, Alfons; Nikolic, Natasa (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Once assumed only to be a waste product of anaerobe glycolytic activity, lactate is now recognized as an energy source in skeletal muscles. While lactate metabolism has been extensively studied in vivo, underlying cellular ...
  • Vil trening in vivo prege skjelettmuskelceller in vitro? 
    Lund, Jenny (Master thesis / Masteroppgave, 2013)
    Bakgrunn/mål: Fysisk aktivitet har en viktig rolle i profylakse og behandling av en rekke metabolske sykdommer som fedme, insulinresistens, metabolsk syndrom og type 2-diabetes. I denne studien ble energimetabolisme undersøkt ...