Browsing Institutt for informatikk by Author "Qiao, Shuo-Wang"

Now showing items 1-3 of 3

  • B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2. 
    du Pré, Fleur; Blazevski, Jana; Dewan, Alisa Elinsdatter; Stamnæs, Jorunn; Kanduri, Chakravarthi; Sandve, Geir Kjetil; Johannesen, Marie Kongshaug; Lindstad, Christian Borgen; Hnida, Kathrin; Fugger, Lars; Melino, Gerry; Qiao, Shuo-Wang; Sollid, Ludvig Magne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in (Ig KI) mice that express a prototypical celiac ...
  • Comprehensive Analysis of CDR3 Sequences in Gluten-Specific T-Cell Receptors Reveals a Dominant R-Motif and Several New Minor Motifs 
    Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Neumann, Ralf Stefan; Christophersen, Asbjørn; Lundin, Knut E. A.; Sandve, Geir Kjetil; Qiao, Shuo-Wang; Sollid, Ludvig M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Gluten-specific CD4+ T cells are drivers of celiac disease (CeD). Previous studies of gluten-specific T-cell receptor (TCR) repertoires have found public TCRs shared across multiple individuals, biased usage of particular ...
  • TCRpower: quantifying the detection power of T-cell receptor sequencing with a novel computational pipeline calibrated by spike-in sequences 
    Dahal-Koirala, Shiva; Balaban, Gabriel; Neumann, Ralf Stefan; Scheffer, Lonneke; Lundin, Knut; Greiff, Victor; Sollid, Ludvig Magne; Qiao, Shuo-Wang; Sandve, Geir Kjetil Ferkingstad (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract T-cell receptor (TCR) sequencing has enabled the development of innovative diagnostic tests for cancers, autoimmune diseases and other applications. However, the rarity of many T-cell clonotypes presents ...