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(Doctoral thesis / Doktoravhandling, 2021)
Despite clear health benefits and recommendations, consumption of vegetables in children remains far too low. Although many studies have focused on increasing vegetable intake by children aged up to 5 years, only a few ...
(Doctoral thesis / Doktoravhandling, 2021)
Organ donor shortage is a global problem, and patients die every day waiting for a transplant. In the field of tissue engineering, a major aim is to grow functional organs and tissues in the lab. Often using the patient’s ...
(Doctoral thesis / Doktoravhandling, 2021)
Osteoarthritis (OA) is the most common joint disease. OA is a complex multietiological disease where several factors and drivers are involved. This thesis is focused on inflammation as a driver and a perpetuator of OA. ...
(Doctoral thesis / Doktoravhandling, 2021)
One in eleven women in Norway will be diagnosed with breast cancer by age 75. Organized mammographic screening can detect early stage breast cancer and reduce deaths from this disease. However, screening involves harms, ...
(Doctoral thesis / Doktoravhandling, 2021)
Cutaneous melanoma is the most rapidly growing malignancy in Norway and is becoming an increasing public health concern. While exposure to ultraviolet radiation (UVR) from the sun and solarium is the primary risk factor, ...
(Doctoral thesis / Doktoravhandling, 2021)
Mechanically ventilated patients experience communication barriers due to the endotracheal tube. In the last decades an increasing amount of critically ill patients are conscious during mechanical ventilation, because this ...
(Doctoral thesis / Doktoravhandling, 2021)
Patients with malignant blood disease treated with allogeneic stem cell transplantation (allo-HSCT) suffer from insufficient energy and protein intake leading to weight loss and malnutrition. Poor nutritional status has ...
(Doctoral thesis / Doktoravhandling, 2021)
With the introduction of genomic selection in cattle breeding, younger bulls without any fertility records have been recruited for semen production. Bull fertility has a major impact on the overall bovine reproductive ...
(Doctoral thesis / Doktoravhandling, 2021)
Efforts to advance our understanding of the brain has led to an exponentially growing number of publications. However, research reporting practices are often insufficient for independent researchers to interpret and replicate ...
(Doctoral thesis / Doktoravhandling, 2021)
One of the most fascinating properties of the brain is synaptic plasticity, which may be defined as activi-ty-dependent modifications of structure and efficacy of synapses. Synaptic plasticity is believed to be the cellular ...
(Doctoral thesis / Doktoravhandling, 2021)
Stroking someone’s skin activates a group of slow-conducting, unmyelinated low-threshold mechanoreceptors considered integral in affective behaviour involving touch. These afferent fibres are referred to as C-tactile (CT) ...
(Doctoral thesis / Doktoravhandling, 2021)
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive selective loss of dopaminergic neurons (DN) in substantia nigra pars compacta (SNpc). The etiology of PD is unknown, though environmental ...
(Doctoral thesis / Doktoravhandling, 2020)
The three-dimensional (3D) organization of chromatin in the mammalian cell nucleus plays an important role in the regulation of gene expression. In her Ph.D. thesis, Anna Frida Forsberg has investigated the impact of ...
(Doctoral thesis / Doktoravhandling, 2020)
Genetically modified mice are important tools in the effort to understand neurodegenerative conditions and identify potential therapeutic targets. A wide range of transgenic mouse models have been developed, but since each ...
(Doctoral thesis / Doktoravhandling, 2020)
Ischemic heart disease and myocardial infarction increase the risk of fatal heart failure via adverse myocardial remodeling. Cardiac cell death during myocardial infarction results in release of pro-inflammatory factors ...
(Doctoral thesis / Doktoravhandling, 2020)
T cells are major players in the immune system. These cells can recognize dangerous antigens through their specific receptors. Harnessing the power of T cells would be beneficial for not only fighting numerous infectious ...
(Doctoral thesis / Doktoravhandling, 2020)
Nearly everybody is infected with varicella zoster virus (VZV), which causes varicella (chickenpox) and herpes zoster (shingles) (HZ). Varicella is usually a benign, but very itchy skin disease, predominantly occurring in ...
(Doctoral thesis / Doktoravhandling, 2020)
The sense of space is important for movement and the formation of memories. Grid cells in the entorhinal cortex are believed to be key components for spatial reasoning. Established theory suggests that brain waves in the ...
(Doctoral thesis / Doktoravhandling, 2020)
Pharmacogenomic screens for personalized cancer therapy are the focused biomedical application in this thesis. Due to the complex relationships between targeted cancer drugs and high-dimensional genomic predictors, we have ...
(Doctoral thesis / Doktoravhandling, 2020)
Background: Uganda, being a low-and-middle income country, struggles with high stunting (low height-for-age) rates which may result in impaired child development. Although there are several causative factors of child ...
(Doctoral thesis / Doktoravhandling, 2020)
This thesis is based on three papers and examines predictors and factors associated with perceived mastery of clinical work among doctors. Important findings are that perceived recording skills at medical school predicted ...
(Doctoral thesis / Doktoravhandling, 2020)
Our brain is constantly challenged to learn new skills and form new memories, while at the same time having to retain stabile memories of previous experiences. One component contributing to stability is a specialized form ...
(Doctoral thesis / Doktoravhandling, 2020)
Background: About 30% of patients in hospitals are malnourished or at risk of malnutrition. Malnutrition is associated with increased morbidity, longer convalescence, prolonged length of hospital stay, higher readmission ...
(Doctoral thesis / Doktoravhandling, 2020)
Lipid droplets are organelles that store neutral lipids. Many metabolic disorders are associated with altered lipid droplet storage. Proteins of the Plin family regulate lipid droplet stability and are potential therapeutic ...
(Doctoral thesis / Doktoravhandling, 2020)
Hip osteoarthritis (OA) may significantly reduce patient’s quality of life because of loss of physical function and of ability to engage in valued activities. A combination of qualitative and quantitative methods was used ...
(Doctoral thesis / Doktoravhandling, 2020)
Cancer treatments are associated with acute and late adverse effects, which may have large negative consequences on health and quality of life. A healthy lifestyle, including adhering to public guidelines of physical ...
(Doctoral thesis / Doktoravhandling, 2020)
Vitamin A is an essential fat-soluble nutrient with important functions in growth, development and the visual process. The major bioactive form of vitamin A, retinoic acid, can stimulate expression of genes involved in the ...
(Doctoral thesis / Doktoravhandling, 2020)
Past research on secretory pathway (SP) provided a deep understanding of the core components that control trafficking between organelles as well as their architecture. However, it is becoming increasingly clear that the ...
(Doctoral thesis / Doktoravhandling, 2020)
Epilepsy is one of the most common neurological diseases affecting about 65 million people worldwide. The disease is characterized by recurrent epileptic seizures either of unknown cause or caused by diverse pathologies ...
(Doctoral thesis / Doktoravhandling, 2020)
The genome has long been believed to be more or less randomly arranged in the nucleus. However, recent advancements in biochemical, microscopy and computational techniques have revealed a hierarchical genome organization ...