Browsing Institutt for medisinske basalfag by Title
Now showing items 1-20 of 1505
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Flutemetamol (18F-Flut) is an [18F]-labelled amyloid PET tracer with increasing availability. The main objectives of this study were to investigate 1) cerebrospinal fluid (CSF) Aβ 1-42 (Aβ42) concentrations associated with ...
-
2.5-fold increased risk of recurrent acute myocardial infarction with familial hypercholesterolemia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)Background and aims A first-time acute myocardial infarction (AMI) is a severe diagnosis that leads to initiation or intensification of lipid-lowering medication to prevent recurrent events. Individuals with familial ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion, 2017)
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp−/− mice exhibit increased sensitivity ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)In vitro derived simplified 3D representations of human organs or organ functionalities are predicted to play a major role in disease modeling, drug development, and personalized medicine, as they complement traditional ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)Genome-wide sequencing technologies enable investigations of the structural properties of the genome in various spatial dimensions. Here, we review computational techniques developed to model the three-dimensional genome ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)In most mammalian cells, DNA replication occurs once, and only once between cell divisions. Replication initiation is a highly regulated process with redundant mechanisms that prevent errant initiation events. In lower ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Background A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure. Using these models, we estimate ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Posttransfusion purpura is a serious adverse effect of transfusion due to HPA-antibodies. A young female was diagnosed with acute leukaemia, and treatment commenced. Severe thrombocytopenia ensued. No platelet increment ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2006)Background Age-related alterations in metabolism and excretion of medications increase the risk of adverse drug events in the elderly. Inappropriate polypharmacy and prescription practice entails increased ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2011)Objectives To address the relative importance of general job-related stressors, ambulance specific stressors and individual characteristics in relation to job satisfaction and health complaints (emotional ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)Background The ever-increasing prevalence of obesity constitutes a major health problem worldwide. A subgroup of obese individuals has been described as “metabolically healthy obese” (MHO). In contrast to ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)The intake of fruit and vegetables is associated with beneficial health outcomes, and studies aimed at increasing fruit and vegetable intake lack long-term follow-up. The primary objective of this study was to evaluate the ...
-
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)The COPII-cargo adaptor complex Lst1-Sec23 selectively sorts proteins into vesicles that bud from the endoplasmic reticulum (ER) and traffic to the Golgi. Improperly folded proteins are prevented from exiting the ER and ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)Background There is considerable evidence that many complex traits have a partially shared genetic basis, termed pleiotropy. It is therefore useful to consider integrating genome-wide association study ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2010)Background Previous research on mental health care has shown considerable differences in use of seclusion, restraint and involuntary medication among different wards and geographical areas. This study ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)Background Diet has a major influence on the composition of the gut microbiota, whose importance for gut health and overall well-being is increasingly recognized. Knowledge is limited regarding health ...
-
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2013)Objectives. To investigate the relationship between the length of a medical consultation in a general practice setting and the biopsychosocial information obtained by the physician, and to explore the characteristics of ...