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Now showing items 501-600 of 674
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Purpose
To examine whether positive associations between alcohol and liver enzymes were modified by coffee consumption, smoking, or weight status in a female population.
Methods
Regular consumption of beer, wine, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that can regulate cytoskeletal dynamics via its ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Therapeutic hypothermia reduces the incidence of severe motor disability, such as cerebral palsy, following neonatal hypoxic-ischaemic encephalopathy. However, cooled children without cerebral palsy at school-age demonstrate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Importance Workplace violence (WPV) is a worldwide problem in health services. Several studies have pointed to organizational factors, such as working in psychiatry and work stress. However, there is a lack of long-term ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract
Background and Objectives
A randomized placebo-controlled trial found a significant negative interaction between aspirin and B vitamins in cognitive functioning in older people with mild ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Objectives:
This study aimed to determine the energy and protein content of meals served and consumed by hospitalised patients compared with their needs, to assess patients’ food satisfaction and investigate associations ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin and Hippo signaling pathways that are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Neurons that signal the angular velocity of head movements (AHV cells) are important for processing visual and spatial information. However, it has been challenging to isolate the sensory modality that drives them and to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Klebsiella species occupy a wide range of environmental and animal niches, and occasionally cause opportunistic infections that are resistant to multiple antibiotics. In particular, Klebsiella pneumoniae (Kpne) has gained ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Motivation: Mapping of chromatin accessibility landscapes in single-cells and the integration with gene expression enables a better understanding of gene regulatory mechanisms defining cell identities and cell-fate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background Lipedema is an underdiagnosed condition in women, characterized by a symmetrical increase in subcutaneous adipose tissue (SAT) in the lower extremities, sparing the trunk. The lipedema SAT has been found to be ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Protection of the health of the athlete is required for high level sporting performance. Acute respiratory illness is the leading cause of illness and can compromise training and competition in athletes. To date the focus ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Introduction Patients with advanced chronic obstructive pulmonary disease (COPD) experience a great symptom burden. Breathlessness is a very frequently reported symptom that negatively affects all aspects of daily life and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
In vertebrates, the anterior pituitary plays a crucial role in regulating several essential physiological processes via the secretion of at least seven peptide hormones by different endocrine cell types. Comparative and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Long-COVID-19 is a proposed syndrome negatively affecting the health of COVID-19 patients. We present data on self-rated health three to eight months after laboratory confirmed COVID-19 disease compared to a control group ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
We examined whether sleep quality and quantity are associated with cortical and memory changes in cognitively healthy participants across the adult lifespan. Associations between self-reported sleep parameters (Pittsburgh ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Haematopoietic stem cell transplantation (HSCT) is a much‐needed service in Tanzania, to provide curative therapy for sickle cell disease (SCD), aplastic anaemia and haematological malignancies. The experience of other ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective
Low total cholesterol has been linked with adverse mental symptoms such as aggression and impulsivity in severe mental disorders (SMDs). This putative association may affect the clinician's decision making about ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background . Infections transmitted from mother to child (MTCT) during pregnancy, childbirth, and breastfeeding contribute significantly to the high infant and childhood morbidity and mortality in sub-Saharan African ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Children and adolescents with a lower socioeconomic position have poorer dietary behaviours compared to their counterparts with a higher socioeconomic position. A better understanding of the mechanisms behind such socioeconomic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background & aims
Children with intestinal failure (IF) receive parental nutrition to ensure adequate growth and development. The aim of this study was to assess micronutrient status in paediatric IF patients receiving ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Literature focusing on the association between sedentary behaviours and physical activity has provided equivocal results and has been dominated by TV viewing as the indicator of sedentary behaviour. There is ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia. Its cleaved fragments, soluble TREM2 (sTREM2), can be measured in the cerebrospinal fluid (CSF). ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
The ever-increasing prevalence of obesity constitutes a major health problem worldwide. A subgroup of obese individuals has been described as “metabolically healthy obese” (MHO). In contrast to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2 (MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here, we used 2D and 3D human brain cultures to ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective
The role of neutrophil extracellular traps (NETs) in acute heart failure is unknown. We recently showed that interleukin 8, a putative NETs stimulator, was associated with myocardial recovery in acute heart ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Current nutritional management of infants born very preterm results in significant deficiency of the essential fatty acids (FAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA). The impact ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Current studies addressing the influence of interleukin-33 or its receptor (IL-33R/ST2) on development of atopic dermatitis-like inflammation in mice have reported conflicting results. We compared the response in single- ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Ciliopathies are clinically and genetically heterogeneous diseases. We studied three patients from two independent families presenting with features of Joubert syndrome: abnormal breathing pattern during infancy, developmental ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
The majority of people with dementia have behavioral and psychological symptoms of dementia (BPSD), including depression, anxiety and agitation. These may be elicited or aggravated by disrupted ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
The National Early Warning Score (NEWS2) is currently recommended in the UK for the risk stratification of COVID-19 patients, but little is known about its ability to detect severe cases. We aimed ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
BAKGRUNN
Covid-19-pneumoni kan gi alvorlig hypoksemisk respirasjonssvikt som krever intensivmedisinsk behandling. Vi ønsket å beskrive covid-19-intensivpasienter som ble behandlet med og uten invasiv ventilasjonsstøtt ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Cell replacement therapies hold great therapeutic potential. Nevertheless, our knowledge of the mechanisms governing the developmental processes is limited, impeding the quality of differentiation protocols. Generating ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Large‐scale in vitro drug sensitivity screens are an important tool in personalized oncology to predict the effectiveness of potential cancer drugs. The prediction of the sensitivity of cancer cell lines to a panel of drugs ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation towards ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract Introduction Intranasal naloxone is widely used to treat opioid overdoses. The advantage of nasal administration compared to injection lies in its suitability for administration by lay people as it is needless. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Disrupted sleep is common among nursing home patients with dementia and is associated with increased agitation, depression, and cognitive impairment. Detecting and treating sleep problems in this population are ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Generating insulin-producing β-cells from human induced pluripotent stem cells is a promising cell replacement therapy for improving or curing insulin-dependent diabetes. The transplantation of end-stages differentiating ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental systems. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objectives: “True” breast cancers, defined as not being visible on prior screening mammograms, are expected to be more aggressive than “missed” cancers, which are visible in retrospect. However, the evidence to support ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
In breast cancer, immunohistochemistry (IHC) subtypes, together with grade and stage, are well-known independent predictors of breast cancer death. Given the immense changes in breast cancer ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
To limit SARS-CoV-2 spread, quarantine and isolation are obligatory in several situations in Norway. We found low self-reported adherence to requested measures among 1,704 individuals (42%; 95% confidence interval: 37–48). ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
CRISPR/Cas9 is a powerful gene‐editing tool allowing for specific gene manipulation at targeted sites in the genome. Here, we used CRISPR/Cas9‐mediated gene editing to introduce single amino acid mutations into proteins ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract BACKGROUND: Iodine is crucial for normal growth and neurodevelopment. Before 1950, goitre caused by iodine deficiency was widespread in Norway, but decreased significantly after mandatory fortification of animal ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Objective:
Limiting SFA intake may minimise the risk of CHD. However, such reduction often leads to increased intake of carbohydrates. We aimed to evaluate associations and the interplay of carbohydrate and SFA intake ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Grapes contain high concentrations of secondary metabolites and antioxidants that have been linked to a reduction of several chronic diseases. Here, we report results of a UK retail survey, which investigated the effect ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Despite a remarkable decline in global child mortality, more than 6 million children died in 2018, of which 0.9 million (15%) deaths occurred among children aged 5 to 14 years, mostly in low- and middle-income countries ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Norwegian children are more frequently hospitalized with influenza than adults. Little is known about the characteristics of these children. Our aim was to investigate the presence of pre-existing risk conditions ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Extracellular matrix (ECM) remodeling is essential for skeletal muscle development and adaption in response to environmental cues such as exercise and injury. The cell surface proteoglycan syndecan-4 has been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Introduction
The use of ketogenic diet as a supplement to antiseizure medication (ASM) in refractory epilepsy has increased the past decades. This high-fat, low-carbohydrate diet mimics the metabolic state of fasting ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Aim
To explore the role of tonic motor unit activity in body temperature control.
Methods
Motor unit activity in soleus and several other skeletal muscles was recorded electromyographically from adult rats placed in a ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Previous studies of fetal death with maternal influenza have been inconsistent. We explored the effect of maternal influenza-like illness (ILI) in pregnancy on the risk of fetal death, distinguishing between diagnoses ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Eukaryotic cells have the capacity to degrade intracellular components through a lysosomal degradation pathway called macroautophagy (henceforth referred to as autophagy) in which superfluous or damaged cytosolic entities ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Factor VII activating protease (FSAP) is a circulating serine protease implicated in thrombosis, atherosclerosis, stroke, and cancer. Using an overexpression strategy, we have systematically investigated the role of protease ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Several publications have addressed the need for a systematic integration of oncological care focused on the tumor and palliative care (PC) focused on the patient with cancer. The exponential ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Lactate treatment has shown a therapeutic potential for several neurological diseases, including Alzheimer’s disease. In order to optimize the administration of lactate for studies in mouse models, we compared blood lactate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings. We carried out a pilot study to investigate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Coeliac disease (CD) is an immune-mediated enteropathy against dietary gluten. The treatment for CD is a strict life-long gluten-free (GF) diet, which has a profound effect on a person’s life. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background
Dyslipidemia and insulin resistance (HOMA-IR) are cardiovascular risk factors prevalent in patients with psychosis. Whether these factors are intrinsic or affected by lifestyle or antipsychotic medication ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose
Renal sympathetic denervation (RDN) is again gaining interest as recent well-designed trials have demonstrated reduced ambulatory blood pressure (BP) after RDN. However, the hemodynamic mechanisms have not been ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
The hospital-adapted A1 group of Enterococcus faecium remains an organism of significant concern in the context of drug-resistant hospital-associated infections. How this pathogen evolves and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background and Aims: Morphological changes in mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) are well-characterized. Yet, it remains elusive whether these are a consequence of seizures or originate from ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder. Effective long-term treatment options are limited, which warrants increased focus on potential modifiable ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Major depressive disorder (MDD) is a prevalent psychiatric condition associated with significant disability, mortality and economic burden. Cognitive behavioral therapy (CBT) and psychodynamic ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Plasma and tissue sulfur amino acid (SAA) availability are crucial for intracellular methylation reactions and cellular antioxidant defense, which are important processes during exercise and in recovery. In this randomized, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Existing evidence on the association between food insecurity and childhood obesity is mixed. In addition, literature from developing countries in general and Ethiopia in particular on the nexus ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Early‐adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual‐level data from 17 prospective studies ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Study design
A national, retrospective, cross-sectional study.
Objectives
To analyze the prevalence of pressure injury (PI), and characteristics associated with PI development in the hospitalized population of persons ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background: Altitude training stresses several physiological and metabolic processes and alters the dietary needs of the athletes. International Olympic Committee (IOC)'s Nutrition Expert Group suggests that athletes should ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Essential for successful interaction with the environment is the human capacity to resolve events in time. Typical event timing paradigms are judgements of simultaneity (SJ) and of temporal order (TOJ). It remains unclear ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Purpose
Sympathetic nervous system (SNS) over-activity is associated with essential hypertension. Renal sympathetic denervation (RDN) possibly lowers office- and ambulatory blood pressure (BP) in patients with ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Ensuring sufficient iodine intake is a public health priority, but we lack knowledge about the status of iodine in a nationally representative population in Norway. We aimed to assess the current iodine status and intake ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Aim
Adult neurogenesis occurs in two major niches in the brain: the subgranular zone of the hippocampal formation and the ventricular‐subventricular zone. Neurogenesis in both niches is reduced in ageing and neurological ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Despite the fact that the estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Background
Recently, a large group of patients with persistent dyspnea, poor physical capacity, and reduced health-related quality of life (HRQoL) following pulmonary embolism (PE) has been identified and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract BayesMallows is an R package for analyzing preference data in the form of rankings with the Mallows rank model, and its finite mixture extension, in a Bayesian framework. The model is grounded on the idea that the ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Aims: To estimate the effect of atorvastatin on muscle symptom intensity in coronary heart disease (CHD) patients with self-perceived statin-associated muscle symptoms (SAMS) and to determine the relationship to blood ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Description of symptoms and signs related to psychotic disorders at the time of the crime is essential in forensic evaluations of legal insanity. Knowledge of the content of forensic reports is important to improve and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Neisseria gonorrhoeae multilocus sequence type (ST)-7827 emerged in a dramatic fashion in Norway in the period 2016–2018. Here, we aim to shed light on the provenance and expansion of this ST. ST-7827 was found to be ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Scope
It is aimed to investigate how intake of high‐fat meals composed of different dairy products with a similar fat content affects postprandial peripheral blood mononuclear cell (PBMC) expression of inflammation‐related ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Background Genetic and clinical observations have indicated T cells are involved in MS pathology. There is little insight in how T cells are involved and whether or not these can be used as markers for MS. Objectives ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We assessed the effect of weight-loss induced with a low-carbohydrate-high-fat diet with and without exercise, on body-composition, cardiorespiratory fitness and cardiovascular risk factors. A total of 57 overweight and ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Enterococcus faecium is a gut commensal of the gastro-digestive tract, but also known as nosocomial pathogen among hospitalized patients. Population genetics based on whole-genome sequencing has revealed that E. faecium ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background
Adults with intellectual disabilities living in residential houses have a high prevalence of obesity which is related to poor dietary habits.
Aim
The aim of this study was to assess supporting staff`s ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
Slow stroking touch activates C-tactile (CT) fibres in the human skin and is typically described as pleasant. Over a longer duration of stroking, affective habituation sets in, indicated by a reduction in rated pleasantness. ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not been quantified during natural sleep. Here, we employ an activity-based algorithm to assess astrocytic Ca2+ signals in the neocortex ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Abstract The time after a breast cancer diagnosis is a potential period for making positive dietary changes, but previous results are conflicting. The main aim of the present study was to study breast cancer patients’ ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
We describe a novel, easy and efficient combinatorial phage display peptide substrate‐mining method to map the substrate specificity of proteases. The peptide library is displayed on the pVII capsid of the M13 bacteriophage, ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Replacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Background
Statins may restrict the cellular functions required for melanoma growth and metastasis.
Objectives
To determine whether long‐term statin use commenced before diagnosis of a primary melanoma is associated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Abstract
STUDY QUESTION
Have mean age at menarche or mean age at natural menopause changed from the 1939 birth cohort to the 1964 birth cohort?
SUMMARY ...
(Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
Objectives Oxidised cholesterol metabolites are linked to increased production of the active vitamin A (Vit-A) form and monocyte/macrophage activation, which may be reflected by neopterin, a marker of both interferon-γ–mediated ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
Mathematical modeling and simulation is a promising approach to personalizedcancer medicine. Yet, the complexity, heterogeneity and multi-scale nature ofcancer pose significant computational challenges. Coupling discrete ...
(Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
Generalized linear models are often misspecified because of overdispersion, heteroscedasticity and ignored nuisance variables. Existing quasi‐likelihood methods for testing in misspecified models often do not provide ...