Browsing Institutt for medisinske basalfag by Title

Now showing items 2751-2770 of 3153

  • T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity 
    Sagan, Sharon A.; Moinfar, Zahra; Moseley, Carson E.; Dandekar, Ravi; Spencer, Collin M.; Verkman, Alan S.; Ottersen, Ole Petter; Sobel, Raymond A.; Sidney, John; Sette, Alessandro; Anderson, Mark S.; Steinman, Lawrence; Wilson, Michael R.; Sabatino, Joseph J.; Zamvil, Scott S. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Aquaporin-4 (AQP4)-specific Th17 cells are thought to have a central role in neuromyelitis optica (NMO) pathogenesis. When modeling NMO, only AQP4-reactive Th17 cells from AQP4-deficient (AQP4−/−), but not wild-type (WT) ...
  • T Cell Metabolism in Infection 
    Wik, Jonas Aakre; Skålhegg, Bjørn Steen (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T cell activation to proliferation, clonal expansion ...
  • T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells 
    Hem, Cecilie D; Sundvold-Gjerstad, Vibeke; Granum, Stine; Koll, Lise; Abrahamsen, Greger; Buday, Laszlo; Spurkland, Anne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details as to how TSAd regulates this process ...
  • t-tests, non-parametric tests, and large studies—a paradox of statistical practice? 
    Fagerland, Morten W (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2012)
    Background During the last 30 years, the median sample size of research studies published in high-impact medical journals has increased manyfold, while the use of non-parametric tests has increased at the ...
  • Tackling cancer cell dormancy: Insights from immune models, and transplantation 
    Corthay, Alexandre; Bakacs, Tibor; Thangavelu, Govindarajan; Anderson, Colin C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Disseminated non-dividing (dormant) cancer cells as well as those in equilibrium with the immune response remain the major challenge for successful treatment of cancer. The equilibrium between disseminated dormant cancer ...
  • TAD cliques predict key features of chromatin organization 
    Liyakat Ali, Tharvesh M.; Brunet, Annaël; Collas, Philippe; Paulsen, Jonas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background Mechanisms underlying genome 3D organization and domain formation in the mammalian nucleus are not completely understood. Multiple processes such as transcriptional compartmentalization, DNA loop ...
  • Tailoring the delivery of cancer diagnosis to adolescent and young adult patients displaying strong emotions: An observational study of two cases 
    Korsvold, Live; Lie, Hanne Cathrine; Mellblom, Anneli; Ruud, Ellen; Loge, Jon Håvard; Finset, Arnstein (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Delivering the bad news of a cancer diagnosis to adolescent and young adult (AYA) patients who display strong emotions is particularly challenging not the least because AYAs are at a vulnerable developmental stage. Due to ...
  • Take a deep breath: Respiratory variations in systemic and cerebral hemodynamics during reduced venous return 
    Holme, Nathalie (Doctoral thesis / Doktoravhandling, 2024)
    This thesis within cardiovascular physiology aimed to explore respiration-related variations in systemic and cerebral hemodynamics in the context of reduced venous return. Steady-state and oscillatory lower body negative ...
  • Tanker om ikke oppnådd behandlingsmål for LDL-kolesterol og eventuelle konsekvenser for livskvalitet og ernæringRestricted Access 
    Saltnes, Lillian (Master thesis / Masteroppgave, 2021)
  • Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models 
    Waaler, Jo; Mygland, Line; Tveita, Anders Aune; Strand, Martin Frank; Solberg, Nina; Olsen, Petter Angell; Aizenshtadt, Aleksandra; Fauskanger, Marte; Lund, Kaja; Mahmuda, Shoshy (Brinch, Shoshy Alam); Lycke, Eric Maximilian; Dybing, Elisabeth; Nygaard, Vegard; Bøe, Sigurd; Heintz, Karen Marie; Hovig, Eivind; Hammarström, Clara Louise; Corthay, Alexandre; Krauss, Stefan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    The development of immune checkpoint inhibitors represents a major breakthrough in cancer therapy. Nevertheless, a substantial number of patients fail to respond to checkpoint pathway blockade. Evidence for WNT/β-catenin ...
  • Target-specific compound selectivity for multi-target drug discovery and repurposing 
    Wang, Tianduanyi; Pulkkinen, Otto I.; Aittokallio, Tero Antero (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Most drug molecules modulate multiple target proteins, leading either to therapeutic effects or unwanted side effects. Such target promiscuity partly contributes to high attrition rates and leads to wasted costs and time ...
  • Targeted deletion of the aquaglyceroporin AQP9 is protective in a mouse model of Parkinson's disease 
    Stahl, Katja; Rahmani, Soulmaz; Prydz, Agnete; Skauli, Nadia; MacAulay, Nanna; Mylonakou, Maria-Niki; Torp, Reidun; Skare, Øivind; Berg, Torill; Leergaard, Trygve Brauns; Paulsen, Ragnhild Elisabeth; Ottersen, Ole Petter; Amiry-Moghaddam, Mahmood (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    More than 90% of the cases of Parkinson's disease have unknown etiology. Gradual loss of dopaminergic neurons of substantia nigra is the main cause of morbidity in this disease. External factors such as environmental toxins ...
  • Targeted deletion of β1-syntrophin causes a loss of Kir 4.1 from Müller cell endfeet in mouse retina 
    Rao, Shreyas Balachandra; Katoozi, Shirin; Skauli, Nadia; Froehner, Stanley C.; Ottersen, Ole Petter; Adams, Marvin E.; Amiry-Moghaddam, Mahmood (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Proper function of the retina depends heavily on a specialized form of retinal glia called Müller cells. These cells carry out important homeostatic functions that are contingent on their polarized nature. Specifically, ...
  • Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway 
    Stukas, Darius; Jasukaitiene, Aldona; Bartkeviciene, Arenida; Matthews, Jason; Maimets, Toivo; Teino, Indrek; Jaudzems, Kristaps; Gulbinas, Antanas; Dambrauskas, Zilvinas (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    The aryl hydrocarbon receptor (AHR) is a transcription factor that is commonly upregulated in pancreatic ductal adenocarcinoma (PDAC). AHR hinders the shuttling of human antigen R (ELAVL1) from the nucleus to the cytoplasm, ...
  • Targeting fatty acid uptake and metabolism in cancer cells: A promising strategy for cancer treatment 
    Mallick, Rahul; Bhowmik, Prasenjit; Duttaroy, Asim Kanti (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Despite scientific development, cancer is still a fatal disease. The development of cancer is thought to be significantly influenced by fatty acids. Several mechanisms that control fatty acid absorption and metabolism are ...
  • Targeting NAD+ in translational research to relieve diseases and conditions of metabolic stress and ageing 
    Gilmour, Brian Christopher; Gudmundsrud, Ruben; Frank, Johannes; Hov, Amund; Hindkjær Lautrup, Sofie; Aman, Yahyah; Røsjø, Helge; Brenner, Charles; Ziegler, Mathias; Tysnes, Ole-Bjørn; Tzoulis, Charalampos; Omland, Torbjørn; Søraas, Arne Vasli; Holmøy, Trygve; Bergersen, Linda Hildegard; Storm-Mathisen, Jon; Nilsen, Hilde; Fang, Evandro Fei (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2020)
    Nicotinamide adenine dinucleotide (NAD+) plays a fundamental role in life and health through the regulation of energy biogenesis, redox homeostasis, cell metabolism, and the arbitration of cell survival via linkages to ...
  • Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo 
    Joel, Mrinal; Mughal, Awais A; Grieg, Zanina; Murrell, Wayne; Palmero, Sheryl; Mikkelsen, Birthe; Fjerdingstad, Hege B; Sandberg, Cecilie J; Behnan, Jinan; Glover, Joel C; Langmoen, Iver A; Stangeland, Biljana (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    Background Glioblastomas are invasive therapy resistant brain tumors with extremely poor prognosis. The Glioma initiating cell (GIC) population contributes to therapeutic resistance and tumor recurrence. ...
  • TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease 
    Herhaus, Lina; Bhaskara, Ramachandra M; Lystad, Alf Håkon; Gestal-Mato, Uxia; Covarrubias-Pinto, Adriana; Bonn, Florian; Simonsen, Anne; Hummer, Gerhard; Dikic, Ivan (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Autophagy is a highly conserved catabolic process through which defective or otherwise harmful cellular components are targeted for degradation via the lysosomal route. Regulatory pathways, involving post‐translational ...
  • TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood 
    Amoriello, Roberta; Chernigovskaia, Mariia; Greiff, Victor; Carnasciali, Alberto; Massacesi, Luca; Barilaro, Alessandro; Repice, Anna Maria; Biagioli, Tiziana; Aldinucci, Alessandra; Muraro, Paolo A.; Laplaud, David-Axel; Lossius, Andreas; Ballerini, Clara (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    Background T cells play a key role in the pathogenesis of multiple sclerosis (MS), a chronic, inflammatory, demyelinating disease of the central nervous system (CNS). Although several studies recently investigated the ...
  • Teachers’ perspectives on the EU Fruit and Vegetable Scheme implementation in Italy 
    Vitali, Veronica; Tiboldo, Giulia; Castellari, Elena; Meshkovska, Biljana (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2023)
    Objective: School-based fruit and vegetable provision programmes can improve children’s eating patterns and health by ensuring access to fruit and vegetables and providing nutrition education. However, the effectiveness ...