Browsing Institutt for medisinske basalfag by Title

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  • Rab7b modulates autophagic flux by interacting with Atg4B 
    Kjos, Ingrid; Distefano, Marita Borg; Sætre, Frank Ove; Repnik, Urska; Holland, Petter; Jones, Arwyn T; Engedal, Nikolai; Simonsen, Anne; Bakke, Oddmund; Progida, Cinzia (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in which cytosolic components and organelles are sequestered by specialized autophagic membranes and degraded through the lysosomal system. ...
  • Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy 
    Chaurasia, Madhuri; Gupta, Swapnil; Das, Asmita; Dwarakanath, B. S.; Simonsen, Anne; Sharma, Kulbhushan (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Cellular effects of ionizing radiation include oxidative damage to macromolecules, unfolded protein response (UPR) and metabolic imbalances. Oxidative stress and UPR have been shown to induce macroautophagy/autophagy in a ...
  • Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters 
    Huynh, Thuy-Tien Maria; Dale, Einar; Falk, Ragnhild Sørum; Hellebust, Taran Annette Paulsen; Astrup, Guro Lindviksmoen; Malinen, Eirik; Edin, Nina Frederike Jeppesen; Bjordal, Kristin; Herlofson, Bente Brokstad; Kiserud, Cecilie E.; Helland, Åslaug; Amdal, Cecilie Delphin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2024)
    Background Although dysphagia is a common side effect after radiotherapy (RT) of head and neck cancer (HNC), data on long-term dysphagia is scarce. We aimed to 1) compare radiation dose parameters in HNC survivors with ...
  • Rank-based Bayesian variable selection for genome-wide transcriptomic analyses 
    Ødegaard, Emilie Eliseussen; Fleischer, Thomas; Vitelli, Valeria (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Variable selection is crucial in high-dimensional omics-based analyses, since it is biologically reasonable to assume only a subset of non-noisy features contributes to the data structures. However, the task is particularly ...
  • Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022 
    Linkevicius, Marius; Bonnin, Rémy A; Alm, Erik; Svartström, Olov; Apfalter, Petra; Hartl, Rainer; Hasman, Henrik; Roer, Louise; Räisänen, Kati; Dortet, Laurent; Pfennigwerth, Niels; Hans, Jörg B; Tóth, Ákos; Buzgó, Lilla; Cormican, Martin; Delappe, Niall; Monaco, Monica; Giufrè, Maria; Hendrickx, Antoni Pa; Samuelsen, Ørjan; Pöntinen, Anna Kaarina; Caniça, Manuela; Manageiro, Vera; Oteo-Iglesias, Jesús; Pérez-Vázquez, María; Westmo, Karin; Mäkitalo, Barbro; Palm, Daniel; Monnet, Dominique L.; Kohlenberg, Anke (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Whole genome sequencing data of 874 Escherichia coli isolates carrying bla NDM-5 from 13 European Union/European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ...
  • Rapid identification of in vitro cell toxicity using an electrochemical membrane screening platform 
    Kohl, Yvonne; William, Nicola; Elje, Elisabeth; Backes, Nadine; Rothbauer, Mario; Srancikova, Annamaria; Rundén-Pran, Elise; El Yamani, Naouale; Korenstein, Rafi; Madi, Lea; Barbul, Alexander; Kozics, Katarina; Sramkova, Monika; Steenson, Karen; Gabelova, Alena; Ertl, Peter; Dusinska, Maria; Nelson, Andrew (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    This study compares the performance and output of an electrochemical phospholipid membrane platform against respective in vitro cell-based toxicity testing methods using three toxicants of different biological action ...
  • Rapid recovery and altered neurochemical dependence of locomotor central pattern generation following lumbar neonatal spinal cord injury 
    Züchner, Mark; Kondratska, Olena; Sylte, Camilla; Glover, Joel; Boulland, Jean-Luc (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2018)
    Following incomplete compression injury in the thoracic spinal cord of neonatal mice 1 day after birth (P1), we previously reported that virtually normal hindlimb locomotor function is recovered within about 3 weeks despite ...
  • Rapid, Cost-Efficient, Enzyme-Free Passaging of Human Pluripotent Stem Cells on Feeder Cells by Ethylenediaminetetraacetic Acid-Mediated Dis-Adhesion 
    Fjerdingstad, Hege Brincker; Glover, Joel Clinton (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Human pluripotent stem cells (human embryonic stem cells, hESCs, and human induced pluripotent stem cells, hiPSCs) were originally cultured on different types of feeder cells for maintenance in an undifferentiated state ...
  • Rapid, Large, and Synchronous Sweat and Cardiovascular Responses Upon Minor Stimuli in Healthy Subjects. Dynamics and Reproducibility 
    Ho, Ai Van Thuy; Toska, Karin; Wesche, Jarlis (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Purpose: The aim of the study was to investigate steady state levels, dynamics and reproducibility of cardiovascular variables and electrodermal activity in different skin areas in response to minor physiological and mental ...
  • Rare Germline Variants Are Associated with Rapid Biochemical Recurrence After Radical Prostate Cancer Treatment: A Pan Prostate Cancer Group Study 
    Burns, Daniel; Anokian, Ezequiel; Saunders, Edward J.; Bristow, Robert G.; Fraser, Michael; Reimand, Jüri; Schlomm, Thorsten; Sauter, Guido; Brors, Benedikt; Korbel, Jan; Weischenfeldt, Joachim; Waszak, Sebastian Martin; Corcoran, Niall M.; Jung, Chol-Hee; Pope, Bernard J.; Hovens, Chris M.; Cancel-Tassin, Géraldine; Cussenot, Olivier; Loda, Massimo; Sander, Chris; Hayes, Vanessa M.; Dalsgaard Sorensen, Karina; Lu, Yong-Jie; Hamdy, Freddie C.; Foster, Christopher S.; Gnanapragasam, Vincent; Butler, Adam; Lynch, Andy G.; Massie, Charlie E.; Woodcock, Dan J.; Cooper, Colin S.; Wedge, David C.; Brewer, Daniel S.; Kote-Jarai, Zsofia; Eeles, Rosalind A. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Background Germline variants explain more than a third of prostate cancer (PrCa) risk, but very few associations have been identified between heritable factors and clinical progression. Objective To find rare germline ...
  • Rate-Limiting Enzymes in Cardiometabolic Health and Aging in Humans 
    Parnell, Laurence D.; McCaffrey, Kira S.; Brooks, Athena W.; Smith, Caren E.; Lai, Chao-Qiang; Christensen, Jacob J.; Wiley, Christopher D.; Ordovas, Jose M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Introduction: Rate-limiting enzymes (RLEs) are innate slow points in metabolic pathways, and many function in bio-processes related to nutrient sensing. Many RLEs carry causal mutations relevant to inherited metabolic ...
  • Re-oxygenation after anoxia induces brain cell death and memory loss in the anoxia-tolerant crucian carp 
    Lefevre, Sjannie; Stecyk, Jonathan A. W.; Torp, May-Kristin; Løvold, Lisa Yuen; Sørensen, Christina; Johansen, Ida Beitnes; Stensløkken, Kåre-Olav; Couturier, Christine; Sloman, Katherine A.; Nilsson, Göran Erik (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Crucian carp (Carassius carassius) survive without oxygen for several months, but it is unknown whether they are able to protect themselves from cell death normally caused by the absence, and particularly return, of oxygen. ...
  • Reaching consensus on definitions for food and physical activity policies: experience from the Policy Evaluation Network 
    Kelly, Liam; Twohig, Cliona; Woods, Cathrine B.; Luszczynska, Aleksandra; Murrin, Celine M.; Lien, Nanna; Meshkovska, Biljana; Kamphuis, Carlijn B.M.; Poelman, Maartje; Terragani, Laura; Forberger, Sarah; Hebestreit, Antje; Ahrens, Wolfgang; Harrington, Janas M. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Background An upsurge in policy evaluation research within public health sciences has led to multi-disciplinary research networks like the ‘Policy Evaluation Network’ (PEN). This ...
  • Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis 
    Kocere, Agnese; Resseguier, Julien; Wohlmann, Jens; Skjeldal, Frode Miltzow; Khan, Shanawaz; Speth, Martin; Dal, Nils-Jørgen Knudsen; Ng, Matthew Yoke Wui; Alonso Rodriguez, Noelia; Scarpa, Edoardo; Rizzello, Loris; Battaglia, Giuseppe; Griffiths, Gareth Wyn; Fenaroli, Federico (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background The developing zebrafish is an emerging tool in nanomedicine, allowing non-invasive live imaging of the whole animal at higher resolution than is possible in the more commonly used mouse models. In addition, ...
  • Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer 
    Elgaaen, Bente Vilming; Dahl, Jørgen Fallås; Bentzen, Anne Gry; Ingebrigtsen, Vibeke Anett; Nilsen, Elisabeth Berge; Vistad, Ingvild; Dørum, Anne; Popova, Olesya; Bjørge, Line; Zucknick, Manuela; Aune, Guro; Lindemann, Kristina Yvonne Kathe (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Objectives The aim of this study was to provide real-world efficacy and safety data on niraparib maintenance treatment in patients with non-germline (gBRCA)1/2 mutated platinum-sensitive recurrent ovarian cancer. Methods ...
  • Realization of the right to adequate food and the nutritional status of land evictees: a case for mothers/caregivers and their children in rural Central Uganda 
    Nahalomo, Aziiza; Iversen, Per O; Rukundo, Peter M; Kaaya, Archileo; Kikafunda, Joyce; Eide, Wenche B; Marais, Maritha; Wamala, Edward; Kabahenda, Margaret (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Background In developing countries like Uganda, the human right to adequate food (RtAF) is inextricably linked to access to land for households to feed themselves directly through production or means for ...
  • Recellularization of decellularized venous grafts using peripheral blood: a critical evaluation 
    Rambøl, Mia Marie-Elisabeth; Hisdal, Jonny; Sundhagen, Jon Otto; Brinchmann, Jan E.; Rosales, Antonio (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Vascular disease is a major cause of death worldwide, and the growing need for replacement vessels is not fully met by autologous grafts or synthetic alternatives. Tissue engineering has emerged as a compelling strategy ...
  • Recommendations for the surveillance of cancer-related fatigue in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group 
    Christen, Salome; Roser, Katharina; Mulder, Renee L.; Ilic, Anica; Lie, Hanne Cathrine; Loonen, Jacqueline J.; Mellblom, Anneli; Kremer, Leontien; Hudson, Melissa M.; Constine, Louis Sandy; Skinner, Roderick; Scheinemann, Katrin; Gilleland Marchak, Jordan; Michel, Gisela (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract Purpose Cancer-related fatigue (CRF) negatively affects the lives of childhood, adolescent, and young adult (CAYA) cancer survivors. We aimed to provide an evidence-based clinical practice guideline (CPG) ...
  • Reconstitution of GABA, Glycine and Glutamate Transporters 
    Danbolt, Niels Christian; López-Corcuera, Beatriz; Zhou, Yun (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract In contrast to water soluble enzymes which can be purified and studied while in solution, studies of solute carrier (transporter) proteins require both that the protein of interest is situated in a phospholipid ...
  • Recovering escherichia coli plasmids in the absence of long-read sequencing data 
    Paganini, Julian A.; Plantinga, Nienke L.; Alonso, Sergio Arredondo; Willems, Rob; Schürch, Anita C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2021)
    The incidence of infections caused by multidrug-resistant E. coli strains has risen in the past years. Antibiotic resistance in E. coli is often mediated by acquisition and maintenance of plasmids. The study of E. coli ...