dc.date.accessioned | 2013-03-12T08:52:50Z | |
dc.date.available | 2013-03-12T08:52:50Z | |
dc.date.issued | 2009 | en_US |
dc.date.submitted | 2009-06-16 | en_US |
dc.identifier.citation | Anwar, Hany Fakhry. Application of an ortho-Formylation Reaction in One-pot Procedures and Natural Product Syntheses. Doktoravhandling, University of Oslo, 2009 | en_US |
dc.identifier.uri | http://hdl.handle.net/10852/12308 | |
dc.description.abstract | This thesis describes the transformation of phenols into ortho-hydroxycinnamates, salicylamines, benzoxazines, and salicylnitriles in good overall yields by simple, regioselective, and one-pot procedures using a combination of MgCl2-Et3N as a base system. These one-pot processes are more economically and environmentally benign than those methods previously reported. The MgCl2-Et3N base system was also used in a regioselective Mannich reaction.<br>
Moreover, the first total synthesis of (±)-powelline was described in 10% overall yield over eight steps using an ortho-formylation reaction and an intramolecular oxidative phenolic coupling reaction as the key reactions.
The first total synthesis of the naturally occurring all-(Z)-5,7-dihydroxy-2-(4,7,10,13,16-nonadecapentaenyl)chromone was also achieved in six steps from the ethyl ester of eicosapentaenoic acid with an overall of 14% yield. | eng |
dc.language.iso | eng | en_US |
dc.relation.haspart | 1. Hany F. Anwar , Lars Skattebøl. Jan Skramstad and Trond Vidar Hansen. A one-pot synthesis of ortho-hydroxycinnamate esters. Tetrahedron lett. , 2005, 46, 5285-5287. The paper is not available in DUO. The published version is available at: http://dx.doi.org/10.1016/j.tetlet.2005.06.017 | |
dc.relation.haspart | 2. Hany F. Anwar, Lars Skattebøl and Trond Vidar Hansen. Synthesis substituted salicylamines and dihydro-2H-1,3-benzoxazines. Tetrahedron, 2007, (63), 9997-10002. The paper is not available in DUO. The published version is available at: http://dx.doi.org/10.1016/j.tet.2007.07.064 | |
dc.relation.haspart | 3. Hany F. Anwar and Trond Vidar Hansen. A one-pot synthesis of substituted salicylnitriles. Tetrahedron Letters, 2008, 49, 4443-4445. The paper is not available in DUO. The published version is available at: http://dx.doi.org/10.1016/j.tetlet.2008.05.006 | |
dc.relation.haspart | 4. Hany F. Anwar and Trond Vidar Hansen. First total synthesis of (+-)-Powelline. SYNLETT, 2008, 17, 2681-2683. The paper is not available in DUO. The published version is available at: http://dx.doi.org/10.1055/s-0028-1083526 | |
dc.relation.uri | http://dx.doi.org/10.1016/j.tetlet.2005.06.017 | |
dc.relation.uri | http://dx.doi.org/10.1016/j.tet.2007.07.064 | |
dc.relation.uri | http://dx.doi.org/10.1016/j.tetlet.2008.05.006 | |
dc.relation.uri | http://dx.doi.org/10.1055/s-0028-1083526 | |
dc.relation.uri | http://dx.doi.org/10.1021/oi802635a | |
dc.title | Application of an ortho-Formylation Reaction in One-pot Procedures and Natural Product Syntheses | en_US |
dc.type | Doctoral thesis | en_US |
dc.date.updated | 2009-07-30 | en_US |
dc.creator.author | Anwar, Hany Fakhry | en_US |
dc.subject.nsi | VDP::568 | en_US |
cristin.unitcode | 152300 | en_US |
cristin.unitname | Farmasøytisk institutt | en_US |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.au=Anwar, Hany Fakhry&rft.title=Application of an ortho-Formylation Reaction in One-pot Procedures and Natural Product Syntheses&rft.inst=University of Oslo&rft.date=2009&rft.degree=Doktoravhandling | en_US |
dc.identifier.urn | URN:NBN:no-22423 | en_US |
dc.type.document | Doktoravhandling | en_US |
dc.identifier.duo | 92894 | en_US |
dc.contributor.supervisor | Associate Professor Trond Vidar Hansen | en_US |
dc.identifier.bibsys | 092853188 | en_US |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/12308/1/DUO_864_Anwar.pdf | |