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Positive and negative modulation of the transactivation potential of the transcription factor c-Myb : novel regulatory mechanisms for a classical proto-oncoprotein

Sæther, Thomas
Doctoral thesis
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dravhandling-saether.pdf (7.738Mb)
Year
2008
Permanent link
http://urn.nb.no/URN:NBN:no-30102

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  • Institutt for molekylær biovitenskap [119]
Abstract
No abstract.
List of papers
Paper I Sæther T, Berge T, Ledsaak M, Matre V, Alm-Kristiansen AH, Dahle O, Aubry F, Gabrielsen OS. (2007) The chromatin remodeling factor Mi-2alpha acts as a novel co-activator for human c-Myb. J Biol Chem 282:13994-14005. The paper is not available in DUO. The published version is available at: https://doi.org/10.1074/jbc.M700755200
Paper II Alm-Kristiansen AH, Sæther T, Matre V, Gilfillan S, Dahle O, Gabrielsen OS. (2008) FLASH acts as a co-activator of the transcription factor c-Myb and localizes to active RNA polymerase II foci. Oncogene 27:4644-4656. The paper is not available in DUO. The published version is available at: https://doi.org/10.1038/onc.2008.105
Paper III Molværsmyr AK, Sæther T, Gilfillan S, Lorenzo PI, Kvaløy H, Matre V, Gabrielsen OS. (2010) A SUMO-regulated activation function controls synergy of c-Myb through a repressor-activator switch leading to differential p300 recruitment. Nucleic Acids Res 38:4970-4984. Author version, the published version is available at: https://doi.org/10.1093/nar/gkq245
Paper IV Sæther T, Pattabiraman DR, Alm-Kristiansen AH, Vogt-Kielland LT, Gonda TJ, Gabrielsen OS. (2011) A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability. Oncogene 30:212-222. Author version, the published version is available at: https://doi.org/10.1038/onc.2010.397
 
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