dc.date.accessioned | 2023-02-27T18:26:13Z | |
dc.date.available | 2023-02-27T18:26:13Z | |
dc.date.created | 2022-11-22T20:13:45Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kvammen, Janne Anita Thomassen, Rut Anne Buechner, Jochen Sitsabesan, Ajitha Bentsen, Beint Sigmund Bechensteen, Anne Grete Henriksen, Christine . Impact of allogeneic hematopoietic stem cell transplantation on nutritional status and intake in children. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 2022, 75(5), 675-682 | |
dc.identifier.uri | http://hdl.handle.net/10852/100460 | |
dc.description.abstract | Objectives:
This study aimed to describe the impact of allogeneic/haploidentical hematopoietic stem cell transplantation on nutritional status and intake in a group of children aged 2 to 18 years.
Methods:
In an observational study, data were collected prospectively. Patients were prescribed individual nutritional support by hospital routines. Anthropometrics were measured pre-transplant at hospital admission and weekly from the day of transplant (day 0) until day +28. z scores for weight, height, and BMI were calculated using Norwegian growth references to assess nutritional status. Pre-transplant diet was assessed on the day of hospitalization. Nutrient provision from enteral nutrition (EN = oral and tube) and parenteral nutrition (PN) was assessed by daily records from day +1 until day +28, or previous discharge, and compared with recommendations (RI) from the Nordic Nutrition Recommendations and ESPGHAN guidelines. Total energy intake was presented as the percentage (%) of basal metabolic rate (BMR) calculated by the Schofield equation. Macro- and micronutrient provisions were presented as medians (interquartile range) and the % of RI.
Results:
Twenty-eight patients, mean age 10.3 years (range 3.5–16.6), were included. Two-thirds (n = 18) had malignant diseases. At admission, mean weight Z-score was −0.3, height z scores −0.7, and BMI Z-score 0.1. Eighteen percent (n = 5) were stunted and 25% (n = 7) had overweight. At admission, 25% (n = 7) had established tube feeding, and 7% (n = 2) also had PN. No significant changes in weight z scores were detected during the studied weeks (P = 0.454). The median daily energy provision was 115% (110–123) of BMR and proteins 1.5 (1.3–1.8) g/kg. EN was provided during a median of 93% of the studied days and provided 21% of the energy. PN was given on a median of 96% of the studied days and provided 79% of energy. RI for vitamins, magnesium, and zinc was met. Provision of copper, iodine, selenium, calcium, and phosphate was below RI.
Conclusions:
Combined EN and PN providing 115% of BMR and 1.5 g/kg protein ensured stable weight by day +28 and covered RI, except for trace elements and minerals. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Impact of allogeneic hematopoietic stem cell transplantation on nutritional status and intake in children | |
dc.title.alternative | ENEngelskEnglishImpact of allogeneic hematopoietic stem cell transplantation on nutritional status and intake in children | |
dc.type | Journal article | |
dc.creator.author | Kvammen, Janne Anita | |
dc.creator.author | Thomassen, Rut Anne | |
dc.creator.author | Buechner, Jochen | |
dc.creator.author | Sitsabesan, Ajitha | |
dc.creator.author | Bentsen, Beint Sigmund | |
dc.creator.author | Bechensteen, Anne Grete | |
dc.creator.author | Henriksen, Christine | |
cristin.unitcode | 185,51,13,20 | |
cristin.unitname | Seksjon for klinisk ernæring | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2078713 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Pediatric Gastroenterology and Nutrition - JPGN&rft.volume=75&rft.spage=675&rft.date=2022 | |
dc.identifier.jtitle | Journal of Pediatric Gastroenterology and Nutrition - JPGN | |
dc.identifier.volume | 75 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 675 | |
dc.identifier.endpage | 682 | |
dc.identifier.doi | https://doi.org/10.1097/MPG.0000000000003592 | |
dc.subject.nvi | VDP::Klinisk medisinske fag: 750VDP::Ernæring: 811 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0277-2116 | |
dc.type.version | PublishedVersion | |