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dc.date.accessioned2021-05-01T19:16:51Z
dc.date.available2021-05-01T19:16:51Z
dc.date.created2021-03-25T11:42:26Z
dc.date.issued2021
dc.identifier.citationDhariwal, Achal Petersen, Fernanda Cristina Junges, Roger . ResistoXplorer: a web-based tool for visual, statistical and exploratory data analysis of resistome data. NAR Genomics and Bioinformatics. 2021, 3
dc.identifier.urihttp://hdl.handle.net/10852/85829
dc.description.abstractAbstract The study of resistomes using whole metagenomic sequencing enables high-throughput identification of resistance genes in complex microbial communities, such as the human microbiome. Over recent years, sophisticated and diverse pipelines have been established to facilitate raw data processing and annotation. Despite the progress, there are no easy-to-use tools for comprehensive visual, statistical and functional analysis of resistome data. Thus, exploration of the resulting large complex datasets remains a key bottleneck requiring robust computational resources and technical expertise, which creates a significant hurdle for advancements in the field. Here, we introduce ResistoXplorer, a user-friendly tool that integrates recent advancements in statistics and visualization, coupled with extensive functional annotations and phenotype collection, to enable high-throughput analysis of common outputs generated from metagenomic resistome studies. ResistoXplorer contains three modules—the ‘Antimicrobial Resistance Gene Table’ module offers various options for composition profiling, functional profiling and comparative analysis of resistome data; the ‘Integration’ module supports integrative exploratory analysis of resistome and microbiome abundance profiles derived from metagenomic samples; finally, the ‘Antimicrobial Resistance Gene List’ module enables users to intuitively explore the associations between antimicrobial resistance genes and the microbial hosts using network visual analytics to gain biological insights. ResistoXplorer is publicly available at http://www.resistoxplorer.no.
dc.languageEN
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleResistoXplorer: a web-based tool for visual, statistical and exploratory data analysis of resistome data
dc.typeJournal article
dc.creator.authorDhariwal, Achal
dc.creator.authorPetersen, Fernanda Cristina
dc.creator.authorJunges, Roger
cristin.unitcode185,16,15,0
cristin.unitnameInstitutt for oral biologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1900987
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NAR Genomics and Bioinformatics&rft.volume=3&rft.spage=&rft.date=2021
dc.identifier.jtitleNAR Genomics and Bioinformatics
dc.identifier.volume3
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1093/nargab/lqab018
dc.identifier.urnURN:NBN:no-88494
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2631-9268
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/85829/1/lqab018.pdf
dc.type.versionPublishedVersion
cristin.articleidlqab018
dc.relation.projectTHON/001
dc.relation.projectNFR/273833
dc.relation.projectNFR/274867


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