Hide metadata

dc.date.accessioned2021-03-20T21:16:19Z
dc.date.available2021-03-20T21:16:19Z
dc.date.created2021-02-09T14:57:36Z
dc.date.issued2020
dc.identifier.citationPanagopoulos, Ioannis Gorunova, Ludmila Lobmaier, Ingvild Victoria Koren Andersen, Kristin Lund-Iversen, Marius Micci, Francesca Heim, Sverre . Fusion of the COL4A5 gene with NR2F2-AS1 in a hemangioma carrying a t(X;15)(q22;q26) chromosomal translocation. Cancer Genomics & Proteomics. 2020, 17(4), 383-390
dc.identifier.urihttp://hdl.handle.net/10852/84323
dc.description.abstractBackground/Aim: Hemangiomas are benign neoplastic proliferations of blood vessels. Cytogenetic information on hemangiomas is limited to four tumors with abnormal karyotypes. We report here a solitary chromosomal translocation and its molecular consequence in a hemangioma. Materials and Methods: A cavernous hemangioma was extirpated from the foot of a 62 years old man and genetically studied with cytogenetic and molecular genetic methodologies. Results: G-Banding analysis of short-term cultured tumor cells yielded the karyotype 46,Y,t(X;15)(q22;q26)[4]/46,XY[12]. RNA sequencing detected fusion of the collagen type IV alpha 5 chain gene (COL4A5 on Xq22.3) with intronic sequences of nuclear receptor subfamily 2 group F member 2 antisense RNA 1 (NR2F2-AS1 on 15q26.2) resulting in a putative COL4A5 truncated protein. The fusion was verified by RT-PCR together with Sanger sequencing and FISH analyses. Conclusion: The involvement of COL4A5 indicates that some hemangiomas have pathogenetic similarities with other benign tumors such as leiomyomas and subungual exostosis.
dc.languageEN
dc.titleFusion of the COL4A5 gene with NR2F2-AS1 in a hemangioma carrying a t(X;15)(q22;q26) chromosomal translocation
dc.typeJournal article
dc.creator.authorPanagopoulos, Ioannis
dc.creator.authorGorunova, Ludmila
dc.creator.authorLobmaier, Ingvild Victoria Koren
dc.creator.authorAndersen, Kristin
dc.creator.authorLund-Iversen, Marius
dc.creator.authorMicci, Francesca
dc.creator.authorHeim, Sverre
cristin.unitcode185,15,29,40
cristin.unitnameSeksjon for biokjemi og molekylærbiologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1888182
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cancer Genomics & Proteomics&rft.volume=17&rft.spage=383&rft.date=2020
dc.identifier.jtitleCancer Genomics & Proteomics
dc.identifier.volume17
dc.identifier.issue4
dc.identifier.startpage383
dc.identifier.endpage390
dc.identifier.doihttps://doi.org/10.21873/cgp.20197
dc.identifier.urnURN:NBN:no-87061
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1109-6535
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/84323/4/383.full.pdf
dc.type.versionPublishedVersion


Files in this item

Appears in the following Collection

Hide metadata