Hide metadata

dc.date.accessioned2021-03-09T21:35:04Z
dc.date.available2021-03-09T21:35:04Z
dc.date.created2021-01-21T10:46:04Z
dc.date.issued2020
dc.identifier.citationStenehjem, Jo S. Støer, Nathalie Charlotte Ghiasvand, Reza Grimsrud, Tom Kristian Babigumira, Ronnie Rees, Judy R. Nilsen, Lill Tove N Johnsen, Bjørn Thorsby, Per Medbøe Veierød, Marit Bragelien Robsahm, Trude Eid . Prediagnostic serum 25-hydroxyvitamin D and melanoma risk. Scientific Reports. 2020, 10:20129, 1-11
dc.identifier.urihttp://hdl.handle.net/10852/83851
dc.description.abstractAbstract Previous studies of serum 25-hydroxyvitamin D (25(OH)D) in relation to melanoma have shown conflicting results. We conducted a nested case–control study of 708 cases and 708 controls, using prediagnostically collected serum, to study 25(OH)D and melanoma risk in the population-based Janus Serum Bank Cohort. Stratified Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for ultraviolet radiation (UVR) indicators and stratified by ambient UVB of residence and body mass index (BMI). Non-linear associations were studied by restricted cubic splines. Missing data were handled with multiple imputation by chained equations. We found an HR of melanoma risk of 1.01 (95% CI: 0.99, 1.04) and an HR imputed of 1.02 (95% CI: 1.00, 1.04) per 5-nmol/L increase. The spline model showed exposure-risk curves with significantly reduced melanoma risk between 60 and 85 nmol/L 25(OH)D (reference 50 nmol/L). Non-significant J-shaped curves were found in sub-analyses of subjects with high ambient UVB of residence and of subjects with BMI < 25 kg/m 2 . Our data did not yield persuasive evidence for an association between 25(OH)D and melanoma risk overall. Serum levels within the medium range might be associated with reduced risk, an association possibly mediated by BMI.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titlePrediagnostic serum 25-hydroxyvitamin D and melanoma risk
dc.typeJournal article
dc.creator.authorStenehjem, Jo S.
dc.creator.authorStøer, Nathalie Charlotte
dc.creator.authorGhiasvand, Reza
dc.creator.authorGrimsrud, Tom Kristian
dc.creator.authorBabigumira, Ronnie
dc.creator.authorRees, Judy R.
dc.creator.authorNilsen, Lill Tove N
dc.creator.authorJohnsen, Bjørn
dc.creator.authorThorsby, Per Medbøe
dc.creator.authorVeierød, Marit Bragelien
dc.creator.authorRobsahm, Trude Eid
cristin.unitcode185,51,15,0
cristin.unitnameAvdeling for biostatistikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1876343
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=10:20129&rft.spage=1&rft.date=2020
dc.identifier.jtitleScientific Reports
dc.identifier.volume10
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41598-020-77155-2
dc.identifier.urnURN:NBN:no-86582
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/83851/1/Stenehjem2020_SciRep_vitdmelanoma.pdf
dc.type.versionPublishedVersion
cristin.articleid20129


Files in this item

Appears in the following Collection

Hide metadata

Attribution 4.0 International
This item's license is: Attribution 4.0 International