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dc.date.accessioned2021-02-14T20:06:45Z
dc.date.available2021-02-14T20:06:45Z
dc.date.created2021-01-11T13:46:35Z
dc.date.issued2020
dc.identifier.citationVidal-Piñeiro, Didac Sneve, Markus Handal Amlien, Inge Kasbohm Grydeland, Håkon Mowinckel, Athanasia Monika Roe, James Michael Sørensen, Øystein Nyberg, Lars Walhovd, Kristine B Fjell, Anders Martin . The Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan. Cerebral Cortex. 2020
dc.identifier.urihttp://hdl.handle.net/10852/83236
dc.description.abstractAbstract It has been suggested that specific forms of cognition in older age rely largely on late-life specific mechanisms. Here instead, we tested using task-fMRI (n = 540, age 6–82 years) whether the functional foundations of successful episodic memory encoding adhere to a principle of lifespan continuity, shaped by developmental, structural, and evolutionary influences. We clustered regions of the cerebral cortex according to the shape of the lifespan trajectory of memory activity in each region so that regions showing the same pattern were clustered together. The results revealed that lifespan trajectories of memory encoding function showed a continuity through life but no evidence of age-specific mechanisms such as compensatory patterns. Encoding activity was related to general cognitive abilities and variations of grey matter as captured by a multi-modal independent component analysis, variables reflecting core aspects of cognitive and structural change throughout the lifespan. Furthermore, memory encoding activity aligned to fundamental aspects of brain organization, such as large-scale connectivity and evolutionary cortical expansion gradients. Altogether, we provide novel support for a perspective on memory aging in which maintenance and decay of episodic memory in older age needs to be understood from a comprehensive life-long perspective rather than as a late-life phenomenon only.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Functional Foundations of Episodic Memory Remain Stable Throughout the Lifespan
dc.typeJournal article
dc.creator.authorVidal-Piñeiro, Didac
dc.creator.authorSneve, Markus Handal
dc.creator.authorAmlien, Inge Kasbohm
dc.creator.authorGrydeland, Håkon
dc.creator.authorMowinckel, Athanasia Monika
dc.creator.authorRoe, James Michael
dc.creator.authorSørensen, Øystein
dc.creator.authorNyberg, Lars
dc.creator.authorWalhovd, Kristine B
dc.creator.authorFjell, Anders Martin
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedfalse
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1869032
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2020
dc.identifier.jtitleCerebral Cortex
dc.identifier.doihttps://doi.org/10.1093/cercor/bhaa348
dc.identifier.urnURN:NBN:no-85968
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1047-3211
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/83236/2/bhaa348.pdf
dc.type.versionPublishedVersion
dc.relation.projectNOTUR/NORSTORE/NS9084S
dc.relation.projectEU/283634
dc.relation.projectEU/725025
dc.relation.projectEU/313440


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