Expression of palladin is associated with disease progression in metastatic high-grade serous carcinoma

Davidson, Ben; Bock, Annika Jøntvedt; Holth, Arild; Nymoen, Dag Andre
Journal article; AcceptedVersion; Peer reviewed
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Item resctricted until:2021-09-04
Year
2020
Permanent link
http://urn.nb.no/URN:NBN:no-84277

CRIStin
1826975

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Original version
Cytopathology. 2020, 31 (6), 572-578, DOI: https://doi.org/10.1111/cyt.12895
Abstract
Objective: To analyze the expression and clinical role of the actin-associated molecule palladin in serous effusions. Methods: PALLD mRNA expression by quantitative RT-PCR (qRT-PCR) was analyzed in 83 high-grade serous carcinoma (HGSC) effusions. Fifteen malignant mesothelioma (MM) effusions and 18 surgical HGSC specimens from the ovary were studied for comparative purposes. Palladin protein expression by immunohistochemistry was analyzed in another series consisting of 261 HGSC effusions. Results: PALLD mRNA was significantly overexpressed in HGSC compared to MM effusions (p