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dc.date.accessioned2020-10-08T18:11:00Z
dc.date.available2020-10-08T18:11:00Z
dc.date.created2020-10-07T09:52:52Z
dc.date.issued2020
dc.identifier.citationGurholt, Tiril Pedersen Lonning, Vera Nerland, Stener Jørgensen, Kjetil Nordbø Haukvik, Unn K. Alloza, Clara Arango, Celso Barth, Claudia Bearden, Carrie E. Berk, Michael Bohman, Hannes Dandash, Orwa Diaz-Caneja, Covadonga M. Edbom, Carl T van Erp, Theo GM Fett, Anne-Kathrin Frangou, Sophia Goldstein, Benjamin I Grigorian, Anahit Jahanshad, Neda James, Anthony C Janssen, Joost Johannessen, Cecilie Karlsgodt, Katherine H.  Kempton, Matthew J. Kochunov, Peter Krabbendam, Lydia Kyriakopoulos, Marinos Lundberg, Mathias MacIntosh, Bradley J. Rund, Bjørn Rishovd Smelror, Runar E Sultan, Alysha Tamnes, Christian Krog Thomopoulos, Sophia I. Vajdi, Ariana Wedervang-Resell, Kirsten Myhre, Anne Margrethe Andreassen, Ole A. Thompson, Paul M Agartz, Ingrid . Intracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium. Human Brain Mapping. 2020
dc.identifier.urihttp://hdl.handle.net/10852/80558
dc.description.abstractEarly‐onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early‐onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early‐onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early‐onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed‐effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = −0.39) and hippocampal (d = −0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early‐onset schizophrenia (d = −0.34) and affective psychosis (d = −0.42), and early‐onset schizophrenia showed lower hippocampal (d = −0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = −0.42). The findings demonstrate a similar pattern of brain alterations in early‐onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intrac
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleIntracranial and subcortical volumes in adolescents with early‐onset psychosis: A multisite mega‐analysis from the ENIGMA consortium
dc.typeJournal article
dc.creator.authorGurholt, Tiril Pedersen
dc.creator.authorLonning, Vera
dc.creator.authorNerland, Stener
dc.creator.authorJørgensen, Kjetil Nordbø
dc.creator.authorHaukvik, Unn K.
dc.creator.authorAlloza, Clara
dc.creator.authorArango, Celso
dc.creator.authorBarth, Claudia
dc.creator.authorBearden, Carrie E.
dc.creator.authorBerk, Michael
dc.creator.authorBohman, Hannes
dc.creator.authorDandash, Orwa
dc.creator.authorDiaz-Caneja, Covadonga M.
dc.creator.authorEdbom, Carl T
dc.creator.authorvan Erp, Theo GM
dc.creator.authorFett, Anne-Kathrin
dc.creator.authorFrangou, Sophia
dc.creator.authorGoldstein, Benjamin I
dc.creator.authorGrigorian, Anahit
dc.creator.authorJahanshad, Neda
dc.creator.authorJames, Anthony C
dc.creator.authorJanssen, Joost
dc.creator.authorJohannessen, Cecilie
dc.creator.authorKarlsgodt, Katherine H. 
dc.creator.authorKempton, Matthew J.
dc.creator.authorKochunov, Peter
dc.creator.authorKrabbendam, Lydia
dc.creator.authorKyriakopoulos, Marinos
dc.creator.authorLundberg, Mathias
dc.creator.authorMacIntosh, Bradley J.
dc.creator.authorRund, Bjørn Rishovd
dc.creator.authorSmelror, Runar E
dc.creator.authorSultan, Alysha
dc.creator.authorTamnes, Christian Krog
dc.creator.authorThomopoulos, Sophia I.
dc.creator.authorVajdi, Ariana
dc.creator.authorWedervang-Resell, Kirsten
dc.creator.authorMyhre, Anne Margrethe
dc.creator.authorAndreassen, Ole A.
dc.creator.authorThompson, Paul M
dc.creator.authorAgartz, Ingrid
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1837803
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Human Brain Mapping&rft.volume=&rft.spage=&rft.date=2020
dc.identifier.jtitleHuman Brain Mapping
dc.identifier.doihttps://doi.org/10.1002/hbm.25212
dc.identifier.urnURN:NBN:no-83651
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1065-9471
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/80558/4/hbm.25212.pdf
dc.type.versionPublishedVersion
cristin.articleidhbm.25212
dc.relation.projectHSØ/2006-186
dc.relation.projectNFR/288083
dc.relation.projectNFR/250358
dc.relation.projectNFR/2137000
dc.relation.projectHSØ/2017112
dc.relation.projectHSØ/2004-259
dc.relation.projectNOTUR/NORSTORE/NS9666S
dc.relation.projectNFR/223273


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