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dc.date.accessioned2020-09-08T17:51:59Z
dc.date.available2020-09-08T17:51:59Z
dc.date.created2020-08-20T11:11:48Z
dc.date.issued2020
dc.identifier.citationNorbom, Linn Christin Bonaventure Rokicki, Jaroslav van der Meer, Dennis Alnæs, Dag Doan, Nhat Trung Moberget, Torgeir Andreassen, Ole Andreas Westlye, Lars Tjelta Tamnes, Christian Krog . Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents. Translational psychiatry. 2020, 10:251
dc.identifier.urihttp://hdl.handle.net/10852/79227
dc.description.abstractHuman brain development involves spatially and temporally heterogeneous changes, detectable across a wide range of magnetic resonance imaging (MRI) measures. Investigating the interplay between multimodal MRI and polygenic scores (PGS) for personality traits associated with mental disorders in youth may provide new knowledge about typical and atypical neurodevelopment. We derived independent components across cortical thickness, cortical surface area, and grey/white matter contrast (GWC) (n = 2596, 3–23 years), and tested for associations between these components and age, sex and-, in a subsample (n = 878), PGS for neuroticism. Age was negatively associated with a single-modality component reflecting higher global GWC, and additionally with components capturing common variance between global thickness and GWC, and several multimodal regional patterns. Sex differences were found for components primarily capturing global and regional surface area (boys > girls), but also regional cortical thickness. For PGS for neuroticism, we found weak and bidirectional associations with a component reflecting right prefrontal surface area. These results indicate that multimodal fusion is sensitive to age and sex differences in brain structure in youth, but only weakly to polygenic load for neuroticism.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleTesting relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents
dc.typeJournal article
dc.creator.authorNorbom, Linn Christin Bonaventure
dc.creator.authorRokicki, Jaroslav
dc.creator.authorvan der Meer, Dennis
dc.creator.authorAlnæs, Dag
dc.creator.authorDoan, Nhat Trung
dc.creator.authorMoberget, Torgeir
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorWestlye, Lars Tjelta
dc.creator.authorTamnes, Christian Krog
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1824253
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational psychiatry&rft.volume=10&rft.spage=&rft.date=2020
dc.identifier.jtitleTranslational psychiatry
dc.identifier.volume10
dc.identifier.doihttps://doi.org/10.1038/s41398-020-00931-1
dc.identifier.urnURN:NBN:no-82335
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2158-3188
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/79227/2/Norbom_2020_TransPsychiaty.pdf
dc.type.versionPublishedVersion
cristin.articleid251
dc.relation.projectNFR/223273
dc.relation.projectNFR/288083
dc.relation.projectNFR/230345
dc.relation.projectHSØ/2019069


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