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dc.date.accessioned2020-08-17T19:12:14Z
dc.date.available2020-08-17T19:12:14Z
dc.date.created2020-06-03T11:34:47Z
dc.date.issued2020
dc.identifier.citationLianne, Schmaal Pozzi, Elena Ho, Tiffany C van Velzen, Laura S Veer, Ilya M Opel, Nils Van Someren, Eus JW Han, Laura KM Aftanas, Lybomir Aleman, Andre Baune, Bernhard T Berger, Klaus Blanken, Tessa F Capitao, Liliana Couvy-Duchesne, Baptiste Cullen, Kathryn R Udo, Dannlowski Davey, Christopher Erwin-Grabner, Tracy Evans, Jennifer Frodl, Thomas Fu, Cynthia HY Godlewska, Beata Gotlib, Ian H. Goya-Maldonado, Roberto Grabe, Hans J. Groenewold, Nynke A. Grotegerd, Dominik Gruber, Oliver Gutman, Boris A. Hall, Geoffrey B Harrison, Ben J Hatton, Sean N. Hermesdorf, Marco Hickie, Ian B. Hilland, Eva Irungu, Benson Jonassen, Rune Kelly, Sinéad Kircher, Tilo Klimes-Dougan, Bonnie Krug, Axel Landrø, Nils Inge Lagopoulos, Jim Leerssen, Jeanne Li, Meng Linden, David EJ MacMaster, Frank P McIntosh, Andrew M. Mehler, David MA Nenadić, Igor Penninx, Brenda WJH Portella, Maria J Reneman, Liesbeth Rentería, Miguel E Sacchet, Matthew D. Sämann, Philipp G. Schrantee, Anouk Sim, Kang Soares, Jair C. Stein, Dan J. Tozzi, Leonardo van Der Wee, Nic JA Van Tol, Marie-Jose Vermeiren, Robert Vives-Gilabert, Yolanda Walter, Henrik Walter, Martin Whalley, Heather C Wittfeld, Katharina Whittle, Sarah Wright, Margaret J Yang, Tony T Zarate, Carlos Thomopoulos, Sophia I. Jahanshad, Neda Thompson, Paul M Veltman, Dick J. . ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing. Translational psychiatry. 2020, 10(1), 1-19
dc.identifier.urihttp://hdl.handle.net/10852/78459
dc.description.abstractA key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
dc.typeJournal article
dc.creator.authorLianne, Schmaal
dc.creator.authorPozzi, Elena
dc.creator.authorHo, Tiffany C
dc.creator.authorvan Velzen, Laura S
dc.creator.authorVeer, Ilya M
dc.creator.authorOpel, Nils
dc.creator.authorVan Someren, Eus JW
dc.creator.authorHan, Laura KM
dc.creator.authorAftanas, Lybomir
dc.creator.authorAleman, Andre
dc.creator.authorBaune, Bernhard T
dc.creator.authorBerger, Klaus
dc.creator.authorBlanken, Tessa F
dc.creator.authorCapitao, Liliana
dc.creator.authorCouvy-Duchesne, Baptiste
dc.creator.authorCullen, Kathryn R
dc.creator.authorUdo, Dannlowski
dc.creator.authorDavey, Christopher
dc.creator.authorErwin-Grabner, Tracy
dc.creator.authorEvans, Jennifer
dc.creator.authorFrodl, Thomas
dc.creator.authorFu, Cynthia HY
dc.creator.authorGodlewska, Beata
dc.creator.authorGotlib, Ian H.
dc.creator.authorGoya-Maldonado, Roberto
dc.creator.authorGrabe, Hans J.
dc.creator.authorGroenewold, Nynke A.
dc.creator.authorGrotegerd, Dominik
dc.creator.authorGruber, Oliver
dc.creator.authorGutman, Boris A.
dc.creator.authorHall, Geoffrey B
dc.creator.authorHarrison, Ben J
dc.creator.authorHatton, Sean N.
dc.creator.authorHermesdorf, Marco
dc.creator.authorHickie, Ian B.
dc.creator.authorHilland, Eva
dc.creator.authorIrungu, Benson
dc.creator.authorJonassen, Rune
dc.creator.authorKelly, Sinéad
dc.creator.authorKircher, Tilo
dc.creator.authorKlimes-Dougan, Bonnie
dc.creator.authorKrug, Axel
dc.creator.authorLandrø, Nils Inge
dc.creator.authorLagopoulos, Jim
dc.creator.authorLeerssen, Jeanne
dc.creator.authorLi, Meng
dc.creator.authorLinden, David EJ
dc.creator.authorMacMaster, Frank P
dc.creator.authorMcIntosh, Andrew M.
dc.creator.authorMehler, David MA
dc.creator.authorNenadić, Igor
dc.creator.authorPenninx, Brenda WJH
dc.creator.authorPortella, Maria J
dc.creator.authorReneman, Liesbeth
dc.creator.authorRentería, Miguel E
dc.creator.authorSacchet, Matthew D.
dc.creator.authorSämann, Philipp G.
dc.creator.authorSchrantee, Anouk
dc.creator.authorSim, Kang
dc.creator.authorSoares, Jair C.
dc.creator.authorStein, Dan J.
dc.creator.authorTozzi, Leonardo
dc.creator.authorvan Der Wee, Nic JA
dc.creator.authorVan Tol, Marie-Jose
dc.creator.authorVermeiren, Robert
dc.creator.authorVives-Gilabert, Yolanda
dc.creator.authorWalter, Henrik
dc.creator.authorWalter, Martin
dc.creator.authorWhalley, Heather C
dc.creator.authorWittfeld, Katharina
dc.creator.authorWhittle, Sarah
dc.creator.authorWright, Margaret J
dc.creator.authorYang, Tony T
dc.creator.authorZarate, Carlos
dc.creator.authorThomopoulos, Sophia I.
dc.creator.authorJahanshad, Neda
dc.creator.authorThompson, Paul M
dc.creator.authorVeltman, Dick J.
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1813609
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational psychiatry&rft.volume=10&rft.spage=1&rft.date=2020
dc.identifier.jtitleTranslational psychiatry
dc.identifier.volume10
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41398-020-0842-6
dc.identifier.urnURN:NBN:no-81531
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2158-3188
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/78459/2/s41398-020-0842-6.pdf
dc.type.versionPublishedVersion
cristin.articleid172


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