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dc.date.accessioned2020-08-14T18:15:50Z
dc.date.available2020-08-14T18:15:50Z
dc.date.created2020-07-20T10:18:34Z
dc.date.issued2020
dc.identifier.citationBJØRNSTAD, JOHANNES Khan, Adil Mahboob Røed-Undlien, Henriette Bendz, Bjørn Nygård, Ståle Hoel, Tom N Lingaas, Per Snorre . Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants. Open heart. 2020, 7(2)
dc.identifier.urihttp://hdl.handle.net/10852/78362
dc.description.abstractThe aim of this study was the analysis of the risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on the proximal aorta due to aortic disease.Methods and resultsData from the department’s register of cardiac surgery was analysed retrospectively with emphasis on operative mortality. 135 non-elective operations for proximal aortic disease (October 2016 to 2018) were identified, of which 19 died during the first 90 days. DOAC use was the top-ranked risk factor in the univariate analysis with a HR of 9.6 (3.1 to 29), p=0.00007. Using a Cox proportional hazards model including the most relevant risk factors, the risk associated with DOAC use remained significant with a HR of 6.1 (1.4 to 26.3), p=0.015. We did not find increased risk associated with warfarin use.In patients undergoing non-elective operations on the proximal aorta due to aortic disease, the use of DOAC is associated with increased operative mortality.
dc.languageEN
dc.publisherBMJ Publishing Group
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleOperative survival in patients with acute aortic disease in the era of newer oral anticoagulants
dc.typeJournal article
dc.creator.authorBJØRNSTAD, JOHANNES
dc.creator.authorKhan, Adil Mahboob
dc.creator.authorRøed-Undlien, Henriette
dc.creator.authorBendz, Bjørn
dc.creator.authorNygård, Ståle
dc.creator.authorHoel, Tom N
dc.creator.authorLingaas, Per Snorre
cristin.unitcode185,53,15,11
cristin.unitnameThoraxkirurgisk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1819830
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Open heart&rft.volume=7&rft.spage=&rft.date=2020
dc.identifier.jtitleOpen heart
dc.identifier.volume7
dc.identifier.issue2
dc.identifier.doihttps://doi.org/10.1136/openhrt-2020-001278
dc.identifier.urnURN:NBN:no-81496
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2053-3624
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/78362/1/e001278.full.pdf
dc.type.versionPublishedVersion
cristin.articleide001278


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