This literature review is an attempt to take a closer look on the existing RCTs on the topic PANS and PANDAS and the child psychiatric investigation and treatment that the participants underwent during submitting to the different studies. In particular it will address the selection of methodology administered to measure the child psychiatric symptoms and treatment response. Methods: PubMed was searched, and 15 articles met the inclusion criterias: (PANS OR PANDAS OR "paediatric autoimmune neuropsychiatric disorder associated with streptococcal infections" OR "paediatric acute-onset neuropsychiatric syndrome"). After a closer perusal, 5 studies ended up as relevant for this review. Results: Only one of the five studies described what type of child psychiatric treatment their participants had underwent. None of the reviewed articles mentions mapping of trauma or other stressful events in the participants. Of child psychiatric mapping tools used for pre-study assessment, two studies applied semistructured screening interviews and the three remaining uses CY-BOCS. The main emphasis in the RCTs are in the somatic treatment. Conclusion: More systematic and standardized assessment and treatment guidelines are needed and will be of great importance for future research studies.