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dc.date.accessioned2020-07-15T18:13:43Z
dc.date.available2020-07-15T18:13:43Z
dc.date.created2019-06-01T13:22:16Z
dc.date.issued2019
dc.identifier.citationPang, Di-Jiang Huang, Chao Chen, Mei-Ling Chen, Yu-Long Fu, Yu-Ping Paulsen, Berit Smestad Rise, Frode Zhang, Bing-Zhao Chen, Zheng-Li Jia, Ren-Yong Li, Li-Xia Song, Xu Feng, Bin Ni, Xue-Qin Yin, Zhong-Qiong Zou, Yuan-Feng . Characterization of Inulin-Type Fructan from Platycodon grandiflorus and Study on Its Prebiotic and Immunomodulating Activity. Molecules. 2019, 24(7)
dc.identifier.urihttp://hdl.handle.net/10852/77955
dc.description.abstractPlatycodon grandiflorus is a plant widely used in traditional Chinese medicine, of which polysaccharides are reported to be the main components responsible for its bio-functions. In this work, the inulin-type fructan (PGF) was obtained by DEAE anion exchange chromatography from the water extracted from P. grandifloras. Characterization was performed with methanolysis, methylation, and NMR and the results showed that PGF is a β-(2-1) linked fructan, with terminal glucose and with a degree of polymerization of 2–10. In order to study its biofunctions, the prebiotic and immunomodulation properties were assayed. We found that PGF exhibited good prebiotic activity, as shown by a promotion on six strains of lactobacillus proliferation. Additionally, the PGF also displayed direct immunomodulation on intestinal epithelial cells and stimulated the expressions of anti-inflammatory factors. These results indicated that the inulin from P. grandiflorus is a potential natural source of prebiotics as well as a potential intestinal immunomodulator, which will be valuable for further studies and new applications.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCharacterization of Inulin-Type Fructan from Platycodon grandiflorus and Study on Its Prebiotic and Immunomodulating Activity
dc.typeJournal article
dc.creator.authorPang, Di-Jiang
dc.creator.authorHuang, Chao
dc.creator.authorChen, Mei-Ling
dc.creator.authorChen, Yu-Long
dc.creator.authorFu, Yu-Ping
dc.creator.authorPaulsen, Berit Smestad
dc.creator.authorRise, Frode
dc.creator.authorZhang, Bing-Zhao
dc.creator.authorChen, Zheng-Li
dc.creator.authorJia, Ren-Yong
dc.creator.authorLi, Li-Xia
dc.creator.authorSong, Xu
dc.creator.authorFeng, Bin
dc.creator.authorNi, Xue-Qin
dc.creator.authorYin, Zhong-Qiong
dc.creator.authorZou, Yuan-Feng
cristin.unitcode185,15,23,20
cristin.unitnameSeksjon for farmasøytisk kjemi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1702043
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecules&rft.volume=24&rft.spage=&rft.date=2019
dc.identifier.jtitleMolecules
dc.identifier.volume24
dc.identifier.issue7
dc.identifier.pagecount12
dc.identifier.doihttps://doi.org/10.3390/molecules24071199
dc.identifier.urnURN:NBN:no-81096
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1420-3049
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/77955/1/Rise_molecules-24-01199.pdf
dc.type.versionPublishedVersion
cristin.articleid1199


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