Risk Indicators of Dental Erosion in Experimental Mouse Models and Humans
Appears in the following Collection
- Det odontologiske fakultet 
AbstractDental erosion is irreversible loss of hard dental substance mostly due to acidic drinks and food. Modern lifestyle and changes in eating habits have led to increased consumption of such products causing an increased prevalence. Still, risk factors and mechanisms of development are unclear as well as the role of salivary components in protection of dental tissue against erosive challenges. This thesis aimed to investigate the risk indicators of dental erosion in experimental mouse models and humans. The first study implemented in this thesis developed a mouse model for comprehensive studying of dental erosion in scanning electron microscope. In the second study, a model of erosion in mice with impaired salivary gland function was developed resulting in more severe erosions compared to control mice and mice with normal salivary gland function. The third study investigated the relationship between factors of environment and genetic factors, i.e. salivary aquaporins in humans. Results pointed at relationship between genes and environment for development of dental erosion in humans. This thesis contributes to further understanding of risk factors of dental erosion.
List of papers
|Paper I: Tulek A, Saeed M, Mulic A, Stenhagen KR, Utheim TP, Galtung HK, Khuu C, Nirvani M, Kristiansen MS, Sehic A. New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth. Arch Oral Biol 2018; 96:137-145. doi:10.1016/j.archoralbio.2018.08.013. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.archoralbio.2018.08.013|
|Paper II: Tulek A, Mulic A, Stenhagen KR, Galtung HK, Saeed M, Utheim TP, Khuu C, Galteland P, Sehic A. Dental erosion in mice with impaired salivary gland function. Acta Odontol Scand 2020; doi:10.1080/00016357.2020.1734234. The article is included in the thesis. Also available at: https://doi.org/10.1080/00016357.2020.1734234|
|Paper III: Tulek A, Vieira AR, Weber ML, Bezamat M, Deeley K, Stenhagen KR, Sehic A, Søvik JB, Mulic A. Aquaporins` influence on different dental erosive wear phenotypes in humans. Caries Res 2020; doi:10.1159/000505965. The article is not available in DUO due to publisher restrictions. The published version is available at: https://doi.org/10.1159/000505965|