dc.date.accessioned | 2020-07-13T18:56:10Z | |
dc.date.available | 2020-07-13T18:56:10Z | |
dc.date.created | 2020-02-06T15:54:42Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Palomo-Guerrero, Marta Fadó, Rut Casas, Maria Pérez-Montero, Marta Baena, Miguel Helmer, Patrick O. Domínguez, José Luis Roig, Aina Serra, Dolors Hayen, Heiko Stenmark, Harald Raiborg, Camilla Casals, Núria . Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. eLIFE. 2019, 8:e51063, 1-26 | |
dc.identifier.uri | http://hdl.handle.net/10852/77856 | |
dc.description.abstract | Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activated protein kinase (AMPK). We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. These results identify CPT1C as a new regulator of anterograde LE/Lys transport in response to malonyl-CoA changes, and give insight into how axon growth is controlled by nutrients. | |
dc.language | EN | |
dc.publisher | eLife Sciences Publications Ltd | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth | |
dc.type | Journal article | |
dc.creator.author | Palomo-Guerrero, Marta | |
dc.creator.author | Fadó, Rut | |
dc.creator.author | Casas, Maria | |
dc.creator.author | Pérez-Montero, Marta | |
dc.creator.author | Baena, Miguel | |
dc.creator.author | Helmer, Patrick O. | |
dc.creator.author | Domínguez, José Luis | |
dc.creator.author | Roig, Aina | |
dc.creator.author | Serra, Dolors | |
dc.creator.author | Hayen, Heiko | |
dc.creator.author | Stenmark, Harald | |
dc.creator.author | Raiborg, Camilla | |
dc.creator.author | Casals, Núria | |
cristin.unitcode | 185,53,2,15 | |
cristin.unitname | Senter for kreftcelle-reprogrammering | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1791725 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=eLIFE&rft.volume=8:e51063&rft.spage=1&rft.date=2019 | |
dc.identifier.jtitle | eLIFE | |
dc.identifier.volume | 8 | |
dc.identifier.startpage | 1 | |
dc.identifier.endpage | 26 | |
dc.identifier.doi | https://doi.org/10.7554/eLife.51063 | |
dc.identifier.urn | URN:NBN:no-80970 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2050-084X | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/77856/2/Sensing%2Bof%2Bnutrients%2Bby%2BCPT1C%2Bregulates%2Blate%2Bendosome-lysosome%2Banterograde%2Btransport%2Band%2Baxon%2Bgrowth.pdf | |
dc.type.version | PublishedVersion | |