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dc.date.accessioned2020-06-29T18:22:38Z
dc.date.available2020-06-29T18:22:38Z
dc.date.created2020-01-16T11:31:16Z
dc.date.issued2020
dc.identifier.citationThibau, Arno Dichter, Alexander A. Vaca, Diana J. Linke, Dirk Goldman, Adrian Kempf, Volkhard A.J. . Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets. Medical Microbiology and Immmunology. 2019, 1-21
dc.identifier.urihttp://hdl.handle.net/10852/77298
dc.description.abstractThe current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleImmunogenicity of trimeric autotransporter adhesins and their potential as vaccine targetsen_US
dc.typeJournal articleen_US
dc.creator.authorThibau, Arno
dc.creator.authorDichter, Alexander A.
dc.creator.authorVaca, Diana J.
dc.creator.authorLinke, Dirk
dc.creator.authorGoldman, Adrian
dc.creator.authorKempf, Volkhard A.J.
cristin.unitcode185,15,29,60
cristin.unitnameSeksjon for genetikk og evolusjonsbiologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1774651
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Medical Microbiology and Immmunology&rft.volume=&rft.spage=1&rft.date=2019
dc.identifier.jtitleMedical Microbiology and Immmunology
dc.identifier.volume209
dc.identifier.issue3
dc.identifier.startpage243
dc.identifier.endpage263
dc.identifier.doihttps://doi.org/10.1007/s00430-019-00649-y
dc.identifier.urnURN:NBN:no-80441
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0300-8584
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/77298/1/Thibau-MMI-2019.pdf
dc.type.versionPublishedVersion
dc.relation.projectEC/H2020/765042


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