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dc.date.accessioned2020-06-26T18:54:00Z
dc.date.available2020-06-26T18:54:00Z
dc.date.created2019-08-21T10:32:59Z
dc.date.issued2020
dc.identifier.citationHilland, Eva Landrø, Nils Inge Harmer, Catherine Browning, Michael Maglanoc, Luigi Angelo Jonassen, Rune . Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial. Journal of Psychiatry & Neuroscience. 2019
dc.identifier.urihttp://hdl.handle.net/10852/77262
dc.description.abstractBackground: Attentional bias modification (ABM) may lead to more adaptive emotion perception and emotion regulation. Understanding the neural basis of these effects may lead to greater precision for the development of future treatments. Task-related functional MRI (fMRI) after ABM training has not been investigated in depression so far. The main aim of this randomized controlled trial was to explore differences in brain activity after ABM training, in response to emotional stimuli. Methods: A total of 134 people with previous depression, who had been treated for depression and had various degrees of residual symptoms, were randomized to 14 days of active ABM or a closely matched placebo training, followed by an fMRI emotion regulation task. The training procedure was a classical dot–probe task with emotional face stimuli. In the active ABM condition, the probes replaced the more positively valenced face of a given pair. As participants implicitly learned to predict the probe location, this would be likely to induce a more positive attentional bias. The placebo condition was identical, except for the contingency of the probe, which appeared equally behind positive and negative stimuli. We compared depression symptoms and subjective ratings of perceived negativity during fMRI between the training groups. We explored brain activation in predefined regions of interest and across the whole brain. We explored activation in areas associated with changes in attentional bias and degree of depression. Results: Compared with the placebo group, the ABM group showed reduced activation in the amygdala and the anterior cingulate cortex when passively viewing negative images. We found no group differences in predefined regions of interest associated with emotion regulation strategies. Response in the temporal cortices was associated with the degree of change in attentional bias and the degree of depressive symptoms in ABM versus placebo. Limitations: These findings should be replicated in other samples of patients with depression, and in studies using fMRI designs that allow analyses of within-group variability from baseline to follow-up. Conclusion: Attentional bias modification training has an effect on brain function in the circuitry associated with emotional appraisal and the generation of affective states. Clinicaltrials.gov identifier: NCT02931487.
dc.languageEN
dc.publisherOvid
dc.titleAttentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial
dc.typeJournal article
dc.creator.authorHilland, Eva
dc.creator.authorLandrø, Nils Inge
dc.creator.authorHarmer, Catherine
dc.creator.authorBrowning, Michael
dc.creator.authorMaglanoc, Luigi Angelo
dc.creator.authorJonassen, Rune
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1717611
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Psychiatry & Neuroscience&rft.volume=&rft.spage=&rft.date=2019
dc.identifier.jtitleJournal of Psychiatry & Neuroscience
dc.identifier.volume45
dc.identifier.issue1
dc.identifier.startpage23
dc.identifier.endpage33
dc.identifier.pagecount11
dc.identifier.doihttps://doi.org/10.1503/jpn.180118
dc.identifier.urnURN:NBN:no-80371
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1180-4882
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/77262/2/ABM_JPN.pdf
dc.type.versionAcceptedVersion
dc.relation.projectHSØ/2015052
dc.relation.projectNFR/229135


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