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dc.date.accessioned2020-06-15T18:34:07Z
dc.date.available2020-12-26T23:45:49Z
dc.date.created2020-01-30T17:51:33Z
dc.date.issued2020
dc.identifier.citationSeglem, Karoline Brobakke Torvik, Fartein Ask Røysamb, Espen Gjerde, Line C. Magnus, Per Reichborn-Kjennerud, Ted Svedberg, Pia Ørstavik, Ragnhild . A Life Course Study of Genetic and Environmental Influences on Work Incapacity. Twin Research and Human Genetics. 2019, 1-7
dc.identifier.urihttp://hdl.handle.net/10852/76967
dc.description.abstractWork incapacity is a major public health challenge and an economic burden to both society and individuals. Understanding the underlying causes is becoming ever more relevant as many countries face an aging workforce. We examined stability and change in genetic and environmental factors influencing work incapacity from age 18 until retirement, and sex differences in these effects. The large population-based sample comprised information from 28,759 twins followed for up to 23 years combined with high-quality national registry data. We measured work incapacity as the total proportion of potential workdays lost due to sickness absence, rehabilitation and disability benefits. Structural equation modeling with twin data indicated moderate genetic influences on work incapacity throughout life in both men and women, with a high degree of genetic stability from young to old adulthood. Environmental influences were mainly age-specific. Our results indicate that largely the same genetic factors influence individual differences in work incapacity throughout young, middle and older adulthood, despite major differences in degree of work incapacity and probable underlying medical causes.
dc.languageEN
dc.titleA Life Course Study of Genetic and Environmental Influences on Work Incapacity
dc.typeJournal article
dc.creator.authorSeglem, Karoline Brobakke
dc.creator.authorTorvik, Fartein Ask
dc.creator.authorRøysamb, Espen
dc.creator.authorGjerde, Line C.
dc.creator.authorMagnus, Per
dc.creator.authorReichborn-Kjennerud, Ted
dc.creator.authorSvedberg, Pia
dc.creator.authorØrstavik, Ragnhild
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1787150
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Twin Research and Human Genetics&rft.volume=&rft.spage=1&rft.date=2019
dc.identifier.jtitleTwin Research and Human Genetics
dc.identifier.volume23
dc.identifier.issue1
dc.identifier.startpage16
dc.identifier.endpage22
dc.identifier.doihttps://doi.org/10.1017/thg.2019.116
dc.identifier.urnURN:NBN:no-80075
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1832-4274
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76967/1/A%2BLife%2BCourse%2BStudy%2Bof%2BGenetic%2Band%2BEnvironmental%2BInfluences%2Bon%2BWork%2BIncapacity.pdf
dc.type.versionPublishedVersion
dc.relation.projectNFR/288083
dc.relation.projectNFR/262700


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