Background: The bacteria Clostridioides difficile (previously known as Clostridium difficile) is the most important cause of diarrhea related to the use of antibiotics and a frequent reason for hospitalization. The impression is that the incidence is increasing in Norway; however, there is little data on incidence and management of Clostridioides difficile infections (CDI) from Norway. The primary aim of this study was to estimate the incidence of CDI in the population of Østfold and to decide where the infection occurred, register known risk factors, treatment, recurrence and mortality. Methods: We conducted a retrospective study of a representative selection of patients with a positive laboratory faecal test for C. difficile at Sykehuset Østfold in the time period January 1st 2017 – June 30th 2019. Results: We identified 261 episodes of CDI involving 246 unique patients; 54,1% were women, mean age was 68,7. We found a total incidence of 99,2 per 100 000 per year from 2017-2019. 34,6% of the cases were hospital onset, 26,8% community-acquired, 32,1% community-onset healthcare facility associated and 6,1% indeterminate. Overall, 79,8% were exposed to antibiotics in the 60 days prior to infection. Exposure to proton pump inhibitors was found in 52,9% of the cases. Recurrence was 19,5% and 30-day all-cause mortality was 11,1%. Conclusion: Our study estimated a high incidence of CDI, and antibiotics was the most frequent risk factor. Since the study is retrospective, it has some limitations. Additional prospective studies are required to estimate a more accurate incidence of CDI in Norway.