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dc.date.accessioned2020-06-04T17:54:44Z
dc.date.available2020-06-04T17:54:44Z
dc.date.created2020-02-04T10:56:59Z
dc.date.issued2020
dc.identifier.citationPham, Thi Ngoc Maria Huong Haugen, Håvard Jostein Reseland, Janne Elin . Fluoride Modification of Titanium Surfaces Enhance Complement Activation. Materials. 2020, 13(3), 684
dc.identifier.urihttp://hdl.handle.net/10852/76623
dc.description.abstractImmediately after dental implant insertion, blood will be in direct contact and interact with the implant surface and activates inflammatory responses and complement cascades within seconds. The aim of the present study was to determine the ability of fluoride-modified titanium surfaces to activate complement cascades using the human buffy coat as model. The buffy coats were exposed to hydrofluoric acid-modified surfaces for a short time and its responses were compared to controls. Identification and quantification of complement cascade biomarkers were conducted using ELISA kits and multianalyte profiling using Luminex. A lower level of C3 at 30 min and increased levels of C4, MIP-4, CRP, and pigment epithelium-derived factor at 360 min were found on modified surfaces as compared to controls. We found no significant differences in the levels of C3a, C5a, C Factor H, α2M, ApoA1, ApoC3, ApoE, Prealbumin, α1AT, and SAP in modified surfaces in the buffy coats. We conclude that titanium surfaces treated with hydrofluoric acid modify the levels of specific biomarkers related to the complement cascade and angiogenesis and, thus, tissue growth, remodeling and repair, as this may play a role in the enhanced clinical performance of fluoride-modified Ti dental implants.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleFluoride Modification of Titanium Surfaces Enhance Complement Activation
dc.typeJournal article
dc.creator.authorPham, Thi Ngoc Maria Huong
dc.creator.authorHaugen, Håvard Jostein
dc.creator.authorReseland, Janne Elin
cristin.unitcode185,16,17,62
cristin.unitnameBiomaterialer
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1790612
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Materials&rft.volume=13&rft.spage=684&rft.date=2020
dc.identifier.jtitleMaterials
dc.identifier.volume13
dc.identifier.issue3
dc.identifier.doihttps://doi.org/10.3390/ma13030684
dc.identifier.urnURN:NBN:no-79760
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1996-1944
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76623/2/materials-13-00684.pdf
dc.type.versionPublishedVersion
cristin.articleid684
dc.relation.projectNFR/231530


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