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dc.date.accessioned2020-06-03T19:02:11Z
dc.date.available2020-06-03T19:02:11Z
dc.date.created2019-06-19T10:31:03Z
dc.date.issued2019
dc.identifier.citationSanz, Mariano Dahlin, Christer Apatzidou, Danae Artzi, Zvi Bozic, Darco Calciolari, Elena De Bruyn, Hugo Dommisch, Henrik Donos, Nicos Eickholz, Peter Ellingsen, Jan Eirik Haugen, Håvard Jostein Herrera, David Lambert, France Layrolle, Pierre Montero, Eduardo Mustafa, Kamal Babikeir Eln Omar, Omar Schliephake, Henning . Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal of Clinical Periodontology. 2019, 46(21), 82-91
dc.identifier.urihttp://hdl.handle.net/10852/76615
dc.description.abstractBackground and Aims To review the regenerative technologies used in bone regeneration: bone grafts, barrier membranes, bioactive factors and cell therapies. Material and Methods Four background review publications served to elaborate this consensus report. Results and Conclusions Biomaterials used as bone grafts must meet specific requirements: biocompatibility, porosity, osteoconductivity, osteoinductivity, surface properties, biodegradability, mechanical properties, angiogenicity, handling and manufacturing processes. Currently used biomaterials have demonstrated advantages and limitations based on the fulfilment of these requirements. Similarly, membranes for guided bone regeneration (GBR ) must fulfil specific properties and potential biological mechanisms to improve their clinical applicability. Pre‐clinical and clinical studies have evaluated the added effect of bone morphogenetic proteins (mainly BMP ‐2) and autologous platelet concentrates (APC s) when used as bioactive agents to enhance bone regeneration. Three main approaches using cell therapies to enhance bone regeneration have been evaluated: (a) “minimally manipulated” whole tissue fractions; (b) ex vivo expanded “uncommitted” stem/progenitor cells; and (c) ex vivo expanded “committed” bone‐/periosteum‐derived cells. Based on the evidence from clinical trials, transplantation of cells, most commonly whole bone marrow aspirates (BMA ) or bone marrow aspirate concentrations (BMAC ), in combination with biomaterial scaffolds has demonstrated an additional effect in sinus augmentation and horizontal ridge augmentation, and comparable bone regeneration to autogenous bone in alveolar cleft repair.
dc.languageEN
dc.titleBiomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration
dc.typeJournal article
dc.creator.authorSanz, Mariano
dc.creator.authorDahlin, Christer
dc.creator.authorApatzidou, Danae
dc.creator.authorArtzi, Zvi
dc.creator.authorBozic, Darco
dc.creator.authorCalciolari, Elena
dc.creator.authorDe Bruyn, Hugo
dc.creator.authorDommisch, Henrik
dc.creator.authorDonos, Nicos
dc.creator.authorEickholz, Peter
dc.creator.authorEllingsen, Jan Eirik
dc.creator.authorHaugen, Håvard Jostein
dc.creator.authorHerrera, David
dc.creator.authorLambert, France
dc.creator.authorLayrolle, Pierre
dc.creator.authorMontero, Eduardo
dc.creator.authorMustafa, Kamal Babikeir Eln
dc.creator.authorOmar, Omar
dc.creator.authorSchliephake, Henning
cristin.unitcode185,16,17,52
cristin.unitnameProtetikk og bittfunksjon
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode2
dc.identifier.cristin1705982
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Clinical Periodontology&rft.volume=46&rft.spage=82&rft.date=2019
dc.identifier.jtitleJournal of Clinical Periodontology
dc.identifier.volume46
dc.identifier.issue21
dc.identifier.startpage82
dc.identifier.endpage91
dc.identifier.doihttps://doi.org/10.1111/jcpe.13123
dc.identifier.urnURN:NBN:no-79718
dc.type.documentTidsskriftartikkel
dc.source.issn0303-6979
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76615/5/20181120_WKG%2B2%2Bdraft%2Bconsensus%2Breport.pdf
dc.type.versionSubmittedVersion


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