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dc.contributor.authorEidet, Jon R
dc.contributor.authorJørstad, Øystein K
dc.contributor.authorFostad, Ida G
dc.contributor.authorOlstad, Ole K
dc.contributor.authorSørland, Ragnhild Ø
dc.contributor.authorMoe, Morten C
dc.contributor.authorPetrovski, Goran
dc.contributor.authorPepaj, Milaim
dc.date.accessioned2020-06-02T05:08:24Z
dc.date.available2020-06-02T05:08:24Z
dc.date.issued2020
dc.identifier.citationJournal of Ophthalmic Inflammation and Infection. 2020 May 27;10(1):13
dc.identifier.urihttp://hdl.handle.net/10852/76577
dc.description.abstractPurpose To determine whether unilateral acute anterior uveitis (AAU) induces ipsilateral changes in the tear fluid proteome. Methods Five patients (25–77 years old) with unilateral AAU were included. Tear fluid samples were obtained using Schirmer’s test strips. The healthy eye served as control. Proteins were identified by liquid chromatography tandem mass spectrometry. Results Two hundred forty-two tear fluid sample proteins were identified, of which 75 were present in at least three patients. Nine proteins were at least 1.5-fold increased, whereas eight were at least 1.5-fold decreased in tears from the diseased eye compared with the healthy eye. APOBEC3A was significantly increased (1.43-fold; P = 0.04), whereas TGM2 was significantly decreased (− 1.21-fold; P = 0.03) in tears from the diseased eye relative to the healthy eye. Ingenuity Pathway Analysis identified LXR/RXR (P < 1.02E−4) as a top canonical pathway. Conclusion Unilateral AAU induced detectable changes in the ipsilateral tear fluid proteome and involvement of the inflammation-associated LXR/RXR pathway.
dc.language.isoeng
dc.rightsThe Author(s); licensee Springer International Publishing Ltd.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleUnilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway
dc.typeJournal article
dc.date.updated2020-06-02T05:08:24Z
dc.creator.authorEidet, Jon R
dc.creator.authorJørstad, Øystein K
dc.creator.authorFostad, Ida G
dc.creator.authorOlstad, Ole K
dc.creator.authorSørland, Ragnhild Ø
dc.creator.authorMoe, Morten C
dc.creator.authorPetrovski, Goran
dc.creator.authorPepaj, Milaim
dc.identifier.doihttps://doi.org/10.1186/s12348-020-00204-4
dc.identifier.urnURN:NBN:no-79674
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76577/1/12348_2020_Article_204.pdf
dc.type.versionPublishedVersion
cristin.articleid13


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