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dc.date.accessioned2020-05-28T18:50:23Z
dc.date.available2020-05-28T18:50:23Z
dc.date.created2019-01-21T15:17:29Z
dc.date.issued2019
dc.identifier.citationGrønning Dale, Maria Teresa Magnus, Per Leirgul, Elisabeth Holmstrøm, Henrik Gjessing, Håkon K. Brodwall, Kristoffer Haugen, Margaretha Stoltenberg, Camilla Øyen, Nina . Intake of sucrose‑sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in offspring: A Norwegian pregnancy cohort study. European Journal of Epidemiology (EJE). 2019, 34(4), 383-396
dc.identifier.urihttp://hdl.handle.net/10852/76394
dc.description.abstractStudies report increased risk of congenital heart defects (CHD) in the offspring of mothers with diabetes, where high blood glucose levels might confer the risk. We explored the association between intake of sucrose-sweetened soft beverages during pregnancy and risk of CHD. Prospective cohort data with 88,514 pregnant women participating in the Norwegian Mother and Child Cohort Study was linked with information on infant CHD diagnoses from national health registers and the Cardiovascular Diseases in Norway Project. Risk ratios were estimated by fitting generalized linear models and generalized additive models. The prevalence of children with CHD was 12/1000 in this cohort (1049/88,514). Among these, 201 had severe and 848 had non-severe CHD (patent ductus arteriosus; valvular pulmonary stenosis; ventricular septal defect; atrial septal defect). Only non-severe CHD was associated with sucrose-sweetened soft beverages. The adjusted risk ratios (aRR) for non-severe CHD was 1.30 (95% CI 1.07–1.58) for women who consumed 25–70 ml/day and 1.27 (95% CI 1.06–1.52) for women who consumed ≥ 70 ml/day when compared to those drinking ≤ 25 ml/day. Dose–response analyses revealed an association between the risk of non-severe CHD and the increasing exposure to sucrose-sweetened soft beverages, especially for septal defects with aRR = 1.26 (95% CI 1.07–1.47) per tenfold increase in daily intake dose. The findings persisted after adjustment for maternal diabetes or after excluding mothers with diabetes (n = 19). Fruit juices, cordial beverages and artificial sweeteners showed no associations with CHD. The findings suggest that sucrose-sweetened soft beverages may affect the CHD risk in offspring.en_US
dc.languageEN
dc.titleIntake of sucrose‑sweetened soft beverages during pregnancy and risk of congenital heart defects (CHD) in offspring: A Norwegian pregnancy cohort studyen_US
dc.typeJournal articleen_US
dc.creator.authorGrønning Dale, Maria Teresa
dc.creator.authorMagnus, Per
dc.creator.authorLeirgul, Elisabeth
dc.creator.authorHolmstrøm, Henrik
dc.creator.authorGjessing, Håkon K.
dc.creator.authorBrodwall, Kristoffer
dc.creator.authorHaugen, Margaretha
dc.creator.authorStoltenberg, Camilla
dc.creator.authorØyen, Nina
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1662361
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Epidemiology (EJE)&rft.volume=34&rft.spage=383&rft.date=2019
dc.identifier.jtitleEuropean Journal of Epidemiology (EJE)
dc.identifier.volume34
dc.identifier.issue4
dc.identifier.startpage383
dc.identifier.endpage396
dc.identifier.doihttps://doi.org/10.1007/s10654-019-00480-y
dc.identifier.urnURN:NBN:no-79486
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0393-2990
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76394/1/Dale%2Bet%2Bal%2B2019.pdf
dc.type.versionAcceptedVersion
dc.relation.projectNFR/262700


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