dc.date.accessioned | 2020-05-28T18:22:49Z | |
dc.date.available | 2020-05-28T18:22:49Z | |
dc.date.created | 2019-10-23T12:31:53Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Ejigu, Yohannes Magnus, Jeanette H. Sundby, Johanne Magnus, Maria Christine . Pregnancy outcome among HIV-infected women on different antiretroviral therapies in Ethiopia: A cohort study. BMJ Open. 2019, 9(8) | |
dc.identifier.uri | http://hdl.handle.net/10852/76383 | |
dc.description.abstract | Objective: The objective of the study was to compare pregnancy outcomes according to maternal antiretroviral treatment (ART) regimens.
Design: A retrospective cohort study.
Participants and settings: Clinical data was extracted from ART exposed pregnancies of HIV-infected Ethiopian women attending antenatal care follow-up in public health facilities in Addis Ababa between February 2010 and October 2016.
Outcomes: The primary outcomes evaluated were preterm birth, low birth weight and small-for-gestational-age.
Results: A total 1663 of pregnancies exposed to ART were included in the analyses. Of these pregnancies, 17% resulted in a preterm birth, 19% in low birth weight and 32% in a small-for-gestational-age baby. Compared with highly active antiretroviral therapy (HAART) initiated during pregnancy, zidovudine monotherapy was less likely to result in preterm birth (adjusted OR 0.35, 95% CI 0.19 to 0.64) and low birth weight (adjusted OR 0.48, 95% CI 0.24 to 0.94). We observed no differential risk of preterm birth, low birth weight and small-for-gestational-age, when comparing women who initiated HAART during pregnancy to women who initiated HAART before conception. The risk for preterm birth was higher in pregnancies exposed to nevirapine-based HAART (adjusted OR 1.44, 95% CI 1.06 to 1.96) compared with pregnancies exposed to efavirenz-based HAART. Comparing nevirapine-based HAART with efavirenz-based HAART indicated no strong evidence of increased risk of low birth weight or small-for-gestational-age.
Conclusions: We observed a higher risk of preterm birth among women who initiated HAART during pregnancy compared with zidovudine monotherapy. Pregnancies exposed to nevirapine-based HAART also had a greater risk of preterm births compared with efavirenz-based HAART. | |
dc.language | EN | |
dc.publisher | BMJ Publishing Group | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Pregnancy outcome among HIV-infected women on different antiretroviral therapies in Ethiopia: A cohort study | |
dc.type | Journal article | |
dc.creator.author | Ejigu, Yohannes | |
dc.creator.author | Magnus, Jeanette H. | |
dc.creator.author | Sundby, Johanne | |
dc.creator.author | Magnus, Maria Christine | |
cristin.unitcode | 185,52,14,0 | |
cristin.unitname | Avdeling for samfunnsmedisin og global helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 1739823 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMJ Open&rft.volume=9&rft.spage=&rft.date=2019 | |
dc.identifier.jtitle | BMJ Open | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 8 | |
dc.identifier.doi | https://doi.org/10.1136/bmjopen-2018-027344 | |
dc.identifier.urn | URN:NBN:no-79492 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2044-6055 | |
dc.identifier.fulltext | Fulltext https://www.duo.uio.no/bitstream/handle/10852/76383/2/Ejigu_2019_Pre.pdf | |
dc.type.version | PublishedVersion | |
cristin.articleid | e027344 | |
dc.relation.project | NFR/262700 | |