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dc.date.accessioned2020-05-26T17:57:09Z
dc.date.available2020-05-26T17:57:09Z
dc.date.created2019-02-18T08:40:49Z
dc.date.issued2019
dc.identifier.citationFredriksen, Mats Egeland, Jens Haavik, Jan Fasmer, Ole Bernt . Individual Variability in Reaction Time and Prediction of Clinical Response to Methylphenidate in Adult ADHD: A Prospective Open Label Study Using Conners’ Continuous Performance Test II. Journal of Attention Disorders. 2019
dc.identifier.urihttp://hdl.handle.net/10852/76284
dc.description.abstractObjective: The aim of this study was to examine whether reaction time parameters in adult patients with ADHD could predict their response to methylphenidate (MPH). Method: Previously unmedicated patients (N = 123) were administered the Conners’ Continuous Performance Test II (CPT II) at baseline and after 6 weeks of treatment with immediate-release MPH. In addition to traditional CPT measures, we extracted intraindividual raw data and analyzed time series using linear and nonlinear mathematical models. Results: Clinical responders, assessed with the Clinical Global Impression-Improvement scale, showed significant normalization of target failures, reduced variability and skewness, and increased complexity of reaction time series after 6 weeks of treatment, while nonresponders showed no significant changes. Prior to treatment, responders had significantly higher variability and skewness, combined with lower complexity, compared with nonresponders. Conclusion: These results show that the CPT test is useful in the evaluation of treatment response to MPH.en_US
dc.languageEN
dc.titleIndividual Variability in Reaction Time and Prediction of Clinical Response to Methylphenidate in Adult ADHD: A Prospective Open Label Study Using Conners’ Continuous Performance Test IIen_US
dc.typeJournal articleen_US
dc.creator.authorFredriksen, Mats
dc.creator.authorEgeland, Jens
dc.creator.authorHaavik, Jan
dc.creator.authorFasmer, Ole Bernt
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1678112
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Attention Disorders&rft.volume=&rft.spage=&rft.date=2019
dc.identifier.jtitleJournal of Attention Disorders
dc.identifier.doihttps://doi.org/10.1177/1087054719829822
dc.identifier.urnURN:NBN:no-79401
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1087-0547
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76284/1/jad_mf_2019.pdf
dc.type.versionAcceptedVersion
cristin.articleid108705471982982


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