Hide metadata

dc.date.accessioned2020-05-22T19:42:28Z
dc.date.available2020-05-22T19:42:28Z
dc.date.created2020-01-22T09:31:21Z
dc.date.issued2019
dc.identifier.citationDue-Tønnessen, Paulina Pinho, Marco C. Emblem, Kyrre E Hald, John K Kanoto, Masafumi Abildgaard, Andreas Sederevicius, Donatas Groote, Inge Rasmus Rapalino, Otto Bjørnerud, Atle . The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma.. Scientific Reports. 2019, 9(1), 19898
dc.identifier.urihttp://hdl.handle.net/10852/76127
dc.description.abstractIn a blind, dual-center, multi-observer setting, we here identify the pre-treatment radiologic features by Magnetic Resonance Imaging (MRI) associated with subsequent treatment options in patients with glioma. Study included 220 previously untreated adult patients from two institutions (94 + 126 patients) with a histopathologically confirmed diagnosis of glioma after surgery. Using a blind, cross-institutional and randomized setup, four expert neuroradiologists recorded radiologic features, suggested glioma grade and corresponding confidence. The radiologic features were scored using the Visually AcceSAble Rembrandt Images (VASARI) standard. Results were retrospectively compared to patient treatment outcomes. Our findings show that patients receiving a biopsy or a subtotal resection were more likely to have a tumor with pathological MRI-signal (by T2-weighted Fluid-Attenuated Inversion Recovery) crossing the midline (Hazard Ratio; HR = 1.30 [1.21–1.87], P < 0.001), and those receiving a biopsy sampling more often had multifocal lesions (HR = 1.30 [1.16–1.64], P < 0.001). For low-grade gliomas (N = 50), low observer confidence in the radiographic readings was associated with less chance of a total resection (P = 0.002) and correlated with the use of a more comprehensive adjuvant treatment protocol (Spearman = 0.48, P < 0.001). This study may serve as a guide to the treating physician by identifying the key radiologic determinants most likely to influence the treatment decision-making process.en_US
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleThe Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma.en_US
dc.typeJournal articleen_US
dc.creator.authorDue-Tønnessen, Paulina
dc.creator.authorPinho, Marco C.
dc.creator.authorEmblem, Kyrre E
dc.creator.authorHald, John K
dc.creator.authorKanoto, Masafumi
dc.creator.authorAbildgaard, Andreas
dc.creator.authorSederevicius, Donatas
dc.creator.authorGroote, Inge Rasmus
dc.creator.authorRapalino, Otto
dc.creator.authorBjørnerud, Atle
cristin.unitcode185,15,4,50
cristin.unitnameBiofysikk og medisinsk fysikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1779701
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific Reports&rft.volume=9&rft.spage=19898&rft.date=2019
dc.identifier.jtitleScientific Reports
dc.identifier.volume9
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41598-019-56333-x
dc.identifier.urnURN:NBN:no-79191
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn2045-2322
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76127/1/s41598-019-56333-x.pdf
dc.type.versionPublishedVersion
cristin.articleid19898


Files in this item

Appears in the following Collection

Hide metadata

Attribution 4.0 International
This item's license is: Attribution 4.0 International