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dc.date.accessioned2020-05-22T18:34:55Z
dc.date.available2020-05-22T18:34:55Z
dc.date.created2019-11-06T16:49:16Z
dc.date.issued2019
dc.identifier.citationAlopaeus, Julia Fredrika Hellfritzsch, Marie Gutowski, Tobias Scherließ, Regina Almeida, Andreia F Sarmento, Bruno Skalko-Basnet, Natasa Tho, Ingunn . Mucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffold. European Journal of Pharmaceutical Sciences. 2019, 142
dc.identifier.urihttp://hdl.handle.net/10852/76099
dc.description.abstractFrom a patient-centric perspective, oromucosal drug delivery is highly attractive due to the ease of administration without the need of swallowing, and improved patient safety. The aim of the presented work was to prepare a buccal film using a self-forming micellar drug solubiliser as the film matrix, combining it with a mucoadhesive polymer for an enhanced retention on the buccal mucosa. Specifically, we propose the use of a graft co-polymer (Soluplus®), as a solubiliser and film former, supplemented with polymers with more hydrophilic properties and known mucoadhesive properties; hydroxypropyl methylcellulose (HPMC) or modified hydroxypropyl pea starch (Lycoat®). The film was manufactured by the solvent casting method. The resulting dual polymer film containing HPMC exhibited resistance to erosion and mucoadhesive properties superior to the control films of single polymers. In an in vitro oral cavity model, these properties were shown to correlate with increased residence time on simulated oral mucosa. Furthermore, all films containing the graft co-polymer showed similar permeability characteristics of furosemide towards buccal TR146 epithelial cells. This work illustrated that it is possible to manufacture dry, solid, dual polymer films containing an advanced drug delivery system with a cheap and simple method. The combination of a graft co-polymer with a mucoadhesive polymer transform into drug solubilising micelles in a mucin-retentive hydrogel scaffold with longer retention time on buccal mucosa for safe and enhanced advanced formulation.en_US
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleMucoadhesive buccal films based on a graft co-polymer – A mucin-retentive hydrogel scaffolden_US
dc.typeJournal articleen_US
dc.creator.authorAlopaeus, Julia Fredrika
dc.creator.authorHellfritzsch, Marie
dc.creator.authorGutowski, Tobias
dc.creator.authorScherließ, Regina
dc.creator.authorAlmeida, Andreia F
dc.creator.authorSarmento, Bruno
dc.creator.authorSkalko-Basnet, Natasa
dc.creator.authorTho, Ingunn
cristin.unitcode185,15,23,10
cristin.unitnameGalenisk farmasi og samfunnsfarmasi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1744700
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Pharmaceutical Sciences&rft.volume=142&rft.spage=&rft.date=2019
dc.identifier.jtitleEuropean Journal of Pharmaceutical Sciences
dc.identifier.volume142
dc.identifier.pagecount15
dc.identifier.doihttps://doi.org/10.1016/j.ejps.2019.105142
dc.identifier.urnURN:NBN:no-79202
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn0928-0987
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/76099/2/artikkel.pdf
dc.type.versionPublishedVersion
cristin.articleid105142


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