Hide metadata

dc.date.accessioned2020-05-19T19:16:34Z
dc.date.available2020-05-19T19:16:34Z
dc.date.created2019-09-08T14:23:48Z
dc.date.issued2019
dc.identifier.citationMäki-Marttunen, Tuomo Kaufmann, Tobias Elvsåshagen, Torbjørn Devor, Anna Djurovic, Srdjan Westlye, Lars Tjelta Linne, Marja-Leena Rietschel, Marcella Schubert, Dirk Borgwardt, Stefan Efrim-Budisteanu, Magdalena Bettella, Francesco Halnes, Geir Hagen, Espen Næss, Solveig Ness, Torbjørn V Moberget, Torgeir Metzner, Christoph Edwards, Andrew G. Fyhn, Marianne Dale, Anders M. Einevoll, Gaute T. Andreassen, Ole Andreas . Biophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.. Frontiers in Psychiatry. 2019, 10(534)
dc.identifier.urihttp://hdl.handle.net/10852/75971
dc.description.abstractThe brain is the most complex of human organs, and the pathophysiology underlying abnormal brain function in psychiatric disorders is largely unknown. Despite the rapid development of diagnostic tools and treatments in most areas of medicine, our understanding of mental disorders and their treatment has made limited progress during the last decades. While recent advances in genetics and neuroscience have a large potential, the complexity and multidimensionality of the brain processes hinder the discovery of disease mechanisms that would link genetic findings to clinical symptoms and behavior. This applies also to schizophrenia, for which genome-wide association studies have identified a large number of genetic risk loci, spanning hundreds of genes with diverse functionalities. Importantly, the multitude of the associated variants and their prevalence in the healthy population limit the potential of a reductionist functional genetics approach as a stand-alone solution to discover the disease pathology. In this review, we outline the key concepts of a “biophysical psychiatry,” an approach that employs large-scale mechanistic, biophysics-founded computational modelling to increase transdisciplinary understanding of the pathophysiology and strive toward robust predictions. We discuss recent scientific advances that allow a synthesis of previously disparate fields of psychiatry, neurophysiology, functional genomics, and computational modelling to tackle open questions regarding the pathophysiology of heritable mental disorders. We argue that the complexity of the increasing amount of genetic data exceeds the capabilities of classical experimental assays and requires computational approaches. Biophysical psychiatry, based on modelling diseased brain networks using existing and future knowledge of basic genetic, biochemical, and functional properties on a single neuron to a microcircuit level, may allow a leap forward in deriving interpretable biomarkers and move the field toward novel treatment options.en_US
dc.languageEN
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleBiophysical Psychiatry—How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.en_US
dc.typeJournal articleen_US
dc.creator.authorMäki-Marttunen, Tuomo
dc.creator.authorKaufmann, Tobias
dc.creator.authorElvsåshagen, Torbjørn
dc.creator.authorDevor, Anna
dc.creator.authorDjurovic, Srdjan
dc.creator.authorWestlye, Lars Tjelta
dc.creator.authorLinne, Marja-Leena
dc.creator.authorRietschel, Marcella
dc.creator.authorSchubert, Dirk
dc.creator.authorBorgwardt, Stefan
dc.creator.authorEfrim-Budisteanu, Magdalena
dc.creator.authorBettella, Francesco
dc.creator.authorHalnes, Geir
dc.creator.authorHagen, Espen
dc.creator.authorNæss, Solveig
dc.creator.authorNess, Torbjørn V
dc.creator.authorMoberget, Torgeir
dc.creator.authorMetzner, Christoph
dc.creator.authorEdwards, Andrew G.
dc.creator.authorFyhn, Marianne
dc.creator.authorDale, Anders M.
dc.creator.authorEinevoll, Gaute T.
dc.creator.authorAndreassen, Ole Andreas
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1722571
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Psychiatry&rft.volume=10&rft.spage=&rft.date=2019
dc.identifier.jtitleFrontiers in Psychiatry
dc.identifier.volume10
dc.identifier.issue534
dc.identifier.pagecount14
dc.identifier.doihttps://doi.org/10.3389/fpsyt.2019.00534
dc.identifier.urnURN:NBN:no-79066
dc.type.documentTidsskriftartikkelen_US
dc.type.peerreviewedPeer reviewed
dc.source.issn1664-0640
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/75971/2/fpsyt-10-00534.pdf
dc.type.versionPublishedVersion
cristin.articleid534


Files in this item

Appears in the following Collection

Hide metadata

Attribution 4.0 International
This item's license is: Attribution 4.0 International