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dc.date.accessioned2020-05-14T19:19:01Z
dc.date.available2020-05-14T19:19:01Z
dc.date.created2018-12-28T17:27:38Z
dc.date.issued2019
dc.identifier.citationMohn, Christine Rund, Bjørn Rishovd . Neurognitive function and symptom remission 2 years after ECT in major depressive disorders. Journal of Affective Disorders. 2019, 246, 368-375
dc.identifier.urihttp://hdl.handle.net/10852/75614
dc.description.abstractBackground There is a lack of knowledge of possible cognitive side effects of electroconvulsive therapy (ECT) beyond the first few months after treatment. We aim to describe cognitive effects and symptom remission 2 years after ECT in major depressive disorders. Method Twenty-seven depression patients were assessed with the MATRICS Consensus Cognitive Battery (MCCB) and the Everyday Memory Questionnaire (EMQ) before and 2 years after ECT. Their scores were compared with those of healthy matches. Depression and remission status were assessed with the Montgomery–Åsberg Depression Rating Scale (MADRS). Main statistical analyses were ANOVAs and linear mixed model tests. Results At baseline, the patient group was significantly impaired on 7 of 10 cognitive tests compared to the control group. Two years later, this gap was reduced to impairment on 5 of 10 tests. Within the patient group, neurocognitive function either increased significantly from baseline to follow-up, or there was no change. Two years after ECT, 62.9% of the patients were in remission. Those in remission reported better subjective memory function, but displayed no different neuropsychological test results, compared to the non-remitters. Limitations Major limitations were low sample size and lack of uniform ECT procedure. Conclusions We found improved neurocognitive function 2 years after ECT. This effect occurred regardless of remission status, suggesting that ECT induces unique cognitive boosting processes.
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleNeurognitive function and symptom remission 2 years after ECT in major depressive disorders
dc.typeJournal article
dc.creator.authorMohn, Christine
dc.creator.authorRund, Bjørn Rishovd
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1647650
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Affective Disorders&rft.volume=246&rft.spage=368&rft.date=2019
dc.identifier.jtitleJournal of Affective Disorders
dc.identifier.volume246
dc.identifier.startpage368
dc.identifier.endpage375
dc.identifier.doihttps://doi.org/10.1016/j.jad.2018.12.083
dc.identifier.urnURN:NBN:no-78707
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0165-0327
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/75614/1/Cognitive%2Bfunction%2B2%2Byears%2BECT%2BMohn%2BRund%2BJAD.pdf
dc.type.versionAcceptedVersion


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