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dc.date.accessioned2020-05-03T19:45:25Z
dc.date.available2020-05-03T19:45:25Z
dc.date.created2019-10-29T09:29:47Z
dc.date.issued2019
dc.identifier.citationCreese, Byron Vassos, Evangelos Bergh, Sverre Athanasiu, Lavinia Johar, Iskandar Rongve, Arvid Medbøen, Ingrid Tøndel Da Silva, Miguel Vasconcelos Aakhus, Eivind Andersen, Fred Bettella, Francesco Brækhus, Anne Djurovic, Srdjan Paroni, Giulia Proitsi, Petroula Saltvedt, Ingvild Seripa, Davide Stordal, Eystein Fladby, Tormod Aarsland, Dag Andreassen, Ole Andreas Ballard, Clive Selbæk, Geir . Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease. Translational psychiatry. 2019, 9:273, 1-10
dc.identifier.urihttp://hdl.handle.net/10852/75071
dc.description.abstractPsychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for schizophrenia, are commonly used in AD + P, suggesting shared mechanisms. Despite this implication, little empirical research has been conducted to examine whether there are mechanistic similarities between AD + P and schizophrenia. In this study, we tested whether polygenic risk score (PRS) for schizophrenia was associated with AD + P. Schizophrenia PRS was calculated using Psychiatric Genomics Consortium data at ten GWAS p value thresholds (PT) in 3111 AD cases from 11 cohort studies characterized for psychosis using validated, standardized tools. Association between PRS and AD + P status was tested by logistic regression in each cohort individually and the results meta-analyzed. The schizophrenia PRS was associated with AD + P at an optimum PT of 0.01. The strongest association was for delusions where a one standard deviation increase in PRS was associated with a 1.18-fold increased risk (95% CI: 1.06–1.3; p = 0.001). These new findings point towards psychosis in AD—and particularly delusions—sharing some genetic liability with schizophrenia and support a transdiagnostic view of psychotic symptoms across the lifespan.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleExamining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
dc.typeJournal article
dc.creator.authorCreese, Byron
dc.creator.authorVassos, Evangelos
dc.creator.authorBergh, Sverre
dc.creator.authorAthanasiu, Lavinia
dc.creator.authorJohar, Iskandar
dc.creator.authorRongve, Arvid
dc.creator.authorMedbøen, Ingrid Tøndel
dc.creator.authorDa Silva, Miguel Vasconcelos
dc.creator.authorAakhus, Eivind
dc.creator.authorAndersen, Fred
dc.creator.authorBettella, Francesco
dc.creator.authorBrækhus, Anne
dc.creator.authorDjurovic, Srdjan
dc.creator.authorParoni, Giulia
dc.creator.authorProitsi, Petroula
dc.creator.authorSaltvedt, Ingvild
dc.creator.authorSeripa, Davide
dc.creator.authorStordal, Eystein
dc.creator.authorFladby, Tormod
dc.creator.authorAarsland, Dag
dc.creator.authorAndreassen, Ole Andreas
dc.creator.authorBallard, Clive
dc.creator.authorSelbæk, Geir
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1741516
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational psychiatry&rft.volume=9:273&rft.spage=1&rft.date=2019
dc.identifier.jtitleTranslational psychiatry
dc.identifier.volume9
dc.identifier.issue1
dc.identifier.doihttps://doi.org/10.1038/s41398-019-0592-5
dc.identifier.urnURN:NBN:no-78147
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn2158-3188
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/75071/1/s41398-019-0592-5.pdf
dc.type.versionPublishedVersion
cristin.articleid273


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Attribution 4.0 International
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