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dc.date.accessioned2020-04-29T09:21:13Z
dc.date.available2020-04-29T09:21:13Z
dc.date.created2018-07-03T13:22:07Z
dc.date.issued2018
dc.identifier.citationHarris, Gerd Marie Eskerud Wood, Mollie Ystrøm, Eivind Nordeng, Hedvig Marie Egeland . Prenatal triptan exposure and neurodevelopmental outcomes in 5-year-old children: Follow-up from the Norwegian Mother and Child Cohort Study. Paediatric and Perinatal Epidemiology. 2018, 32(3), 247-255
dc.identifier.urihttp://hdl.handle.net/10852/74955
dc.description.abstractBackground Triptans are commonly used to treat migraine headaches, but data on the long‐term safety of these medications during pregnancy are sparse. Triptans have a biologically plausible mechanism for effects on the fetal brain through binding to 5‐HT1‐receptors, and previous studies show increased risks of externalising behaviour problems in toddlers exposed to triptans during pregnancy. Methods We included 3784 children in the Norwegian Mother and Child Cohort Study, whose mothers returned the 5‐year‐questionnaire and reported a history of migraine or triptan use; 353 (9.3%) mothers reported use of triptans during pregnancy, 1509 (39.9%) reported migraine during pregnancy but no triptan use, and 1922 (50.8%) had migraine prior to pregnancy only. We used linear and log‐binomial models with inverse probability weights to examine the association between prenatal triptan exposure and internalising and externalising behaviour, communication, and temperament in 5‐year‐old children. Results Triptan‐exposed children scored higher on the sociability trait than unexposed children of mothers with migraine (β 1.66, 95% confidence interval [0.30, 3.02]). We found no other differences in temperament, or increased risk of behaviour or communication problems. Conclusions Contrary to results from previous studies in younger children, we found no increased risk of externalising behaviour problems in 5‐year‐old children exposed to triptans in fetal life. Triptan‐exposed children did have slightly more sociable temperaments, but the clinical meaning of this finding is uncertain.
dc.languageEN
dc.publisherBlackwell Science Ltd.
dc.titlePrenatal triptan exposure and neurodevelopmental outcomes in 5-year-old children: Follow-up from the Norwegian Mother and Child Cohort Study
dc.typeJournal article
dc.creator.authorHarris, Gerd Marie Eskerud
dc.creator.authorWood, Mollie
dc.creator.authorYstrøm, Eivind
dc.creator.authorNordeng, Hedvig Marie Egeland
cristin.unitcode185,15,23,10
cristin.unitnameGalenisk farmasi og samfunnsfarmasi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1595440
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Paediatric and Perinatal Epidemiology&rft.volume=32&rft.spage=247&rft.date=2018
dc.identifier.jtitlePaediatric and Perinatal Epidemiology
dc.identifier.volume32
dc.identifier.issue3
dc.identifier.startpage247
dc.identifier.endpage255
dc.identifier.doihttps://doi.org/10.1111/ppe.12461
dc.identifier.urnURN:NBN:no-78018
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0269-5022
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74955/1/Eskerud%2BHarris%2Bet%2Bal.%2BPrenatal%2Btriptan%2Bexposure%2Band%2Bneurodevelopmental%2Boutcomes%2Bin%2B5-year-old%2Bchildren.pdf
dc.type.versionAcceptedVersion


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