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dc.date.accessioned2020-04-28T19:29:08Z
dc.date.available2020-04-28T19:29:08Z
dc.date.created2019-11-27T14:15:12Z
dc.date.issued2020
dc.identifier.citationHoekzema, Elseline Tamnes, Christian Krog Berns, Puck Barba-Muller, Erika Pozzobon, Cristina Picado, Marisol Lucco, Florencio Martinez-Garcia, Magdalena Desco, Manuel Ballesteros, Agustin Crone, Eveline A. Vilarroya, Oscar Carmona, Susanna . Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues. Psychoneuroendocrinology. 2019
dc.identifier.urihttp://hdl.handle.net/10852/74944
dc.description.abstractIn mothers, offspring cues are associated with a powerful reinforcing value that motivates maternal care. Animal studies show that this is mediated by dopamine release into the nucleus accumbens, a core component of the brain’s reward system located in the ventral striatum (VStr). The VStr is also known to respond to infant signals in human mothers. However, it is unknown whether pregnancy modifies the anatomy or functionality of this structure, and whether such modifications underlie its strong reactivity to offspring cues. Therefore, we analyzed structural and functional neuroimaging data from a unique pre-conception prospective cohort study involving first-time mothers investigated before and after their pregnancy as well as nulliparous control women scanned at similar time intervals. First, we delineated the anatomy of the VStr in each subject’s neuroanatomical space and examined whether there are volumetric changes in this structure across sessions. Then, we tested if these changes could predict the mothers’ brain responses to visual stimuli of their infants. We found decreases in the right VStr and a trend for left VStr reductions in the women who were pregnant between sessions compared to the women who were not. Furthermore, VStr volume reductions across pregnancy were associated with infant-related VStr responses in the postpartum period, with stronger volume decreases predicting stronger functional activation to offspring cues. These findings provide the first indications that the transition to motherhood renders anatomical adaptations in the VStr that promote the strong responsiveness of a mother’s reward circuit to cues of her infant.
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleBecoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues
dc.typeJournal article
dc.creator.authorHoekzema, Elseline
dc.creator.authorTamnes, Christian Krog
dc.creator.authorBerns, Puck
dc.creator.authorBarba-Muller, Erika
dc.creator.authorPozzobon, Cristina
dc.creator.authorPicado, Marisol
dc.creator.authorLucco, Florencio
dc.creator.authorMartinez-Garcia, Magdalena
dc.creator.authorDesco, Manuel
dc.creator.authorBallesteros, Agustin
dc.creator.authorCrone, Eveline A.
dc.creator.authorVilarroya, Oscar
dc.creator.authorCarmona, Susanna
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedfalse
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin1753132
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.volume=&rft.spage=&rft.date=2019
dc.identifier.jtitlePsychoneuroendocrinology
dc.identifier.volume112
dc.identifier.doihttps://doi.org/10.1016/j.psyneuen.2019.104507
dc.identifier.urnURN:NBN:no-78056
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0306-4530
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74944/4/1-s2.0-S030645301931248X-main.pdf
dc.type.versionPublishedVersion
cristin.articleid104507
dc.relation.projectNFR/223273
dc.relation.projectNFR/288083
dc.relation.projectNFR/230345


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