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dc.date.accessioned2020-04-28T18:57:37Z
dc.date.created2019-12-03T12:05:56Z
dc.date.issued2020
dc.identifier.citationFjell, Anders Martin Sederevicius, Donatas Sneve, Markus Handal de Lange, Ann-Marie Glasø Bråthen, Anne Cecilie Sjøli Idland, Ane-Victoria Watne, Leiv Otto Wang, Yunpeng Reinbold, Céline Sonja Blennow, Kaj Zetterberg, Henrik Hong, S Bertram, Lars Walhovd, Kristine B . Self-reported sleep problems are related to amyloid deposition in cortical regions with high HOMER1 gene expression. Cerebral Cortex. 2019
dc.identifier.urihttp://hdl.handle.net/10852/74930
dc.description.abstractSleep problems are related to the elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ). Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified in rodents. A major marker of sleep deprivation is Homer1a, a neural protein coded by the HOMER1 gene, which has also been implicated in brain Aβ accumulation. Here, we tested whether the relationship between cortical Aβ accumulation and self-reported sleep quality, as well as changes in sleep quality over 3 years, was stronger in cortical regions with high HOMER1 mRNA expression levels. In a sample of 154 cognitively healthy older adults, Aβ correlated with poorer sleep quality cross-sectionally and longitudinally (n = 62), but more strongly in the younger than in older individuals. Effects were mainly found in regions with high expression of HOMER1. The anatomical distribution of the sleep-Aβ relationship followed closely the Aβ accumulation pattern in 69 patients with mild cognitive impairment or AD. Thus, the results indicate that the relationship between sleep problems and Aβ accumulation may involve Homer1 activity in the cortical regions, where harbor Aβ deposits in AD. The findings may advance our understanding of the relationship between sleep problems and AD risk.
dc.languageEN
dc.titleSelf-reported sleep problems are related to amyloid deposition in cortical regions with high HOMER1 gene expression
dc.typeJournal article
dc.creator.authorFjell, Anders Martin
dc.creator.authorSederevicius, Donatas
dc.creator.authorSneve, Markus Handal
dc.creator.authorde Lange, Ann-Marie Glasø
dc.creator.authorBråthen, Anne Cecilie Sjøli
dc.creator.authorIdland, Ane-Victoria
dc.creator.authorWatne, Leiv Otto
dc.creator.authorWang, Yunpeng
dc.creator.authorReinbold, Céline Sonja
dc.creator.authorBlennow, Kaj
dc.creator.authorZetterberg, Henrik
dc.creator.authorHong, S
dc.creator.authorBertram, Lars
dc.creator.authorWalhovd, Kristine B
dc.date.embargoenddate2020-11-11
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2
dc.identifier.cristin1755986
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral Cortex&rft.volume=&rft.spage=&rft.date=2019
dc.identifier.jtitleCerebral Cortex
dc.identifier.volume30
dc.identifier.issue4
dc.identifier.startpage2144
dc.identifier.endpage2156
dc.identifier.doihttps://doi.org/10.1093/cercor/bhz228
dc.identifier.urnURN:NBN:no-78049
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1047-3211
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74930/2/fjell_etal_self_reported_sleep_problems.pdf
dc.type.versionAcceptedVersion
dc.relation.projectNOTUR/NORSTORE/NS9084S


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