Hide metadata

dc.date.accessioned2020-04-24T19:37:24Z
dc.date.available2020-04-24T19:37:24Z
dc.date.created2019-10-07T15:11:56Z
dc.date.issued2020
dc.identifier.citationZeltz, Cedric Primac, Irina Murugan Erusappan, Pugazendhi Alam, Jahedul Noel, Agnes Gullberg, Donald . Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins. Seminars in Cancer Biology. 2019, 1-16
dc.identifier.urihttp://hdl.handle.net/10852/74836
dc.description.abstractThe tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM) macromolecules filled with a collection of cells including cancer-associated fibroblasts (CAFs), blood vessel associated smooth muscle cells, pericytes, endothelial cells, mesenchymal stem cells and a variety of immune cells. In tumors the homeostasis governing ECM synthesis and turnover is disturbed resulting in abnormal blood vessel formation and excessive fibrillar collagen accumulations of varying stiffness and organization. The disturbed ECM homeostasis opens up for new types of paracrine, cell-cell and cell-ECM interactions with large consequences for tumor growth, angiogenesis, metastasis, immune suppression and resistance to treatments. As a main producer of ECM and paracrine signals the CAF is a central cell type in these events. Whereas the paracrine signaling has been extensively studied in the context of tumor-stroma interactions, the nature of the numerous integrin-mediated cell-ECM interactions occurring in the TME remains understudied. In this review we will discuss and dissect the role of known and potential CAF interactions in the TME, during both tumorigenesis and chemoresistance-induced events, with a special focus on the “interaction landscape” in desmoplastic breast, lung and pancreatic cancers. As an example of the multifaceted mode of action of the stromal collagen receptor integrin α11β1, we will summarize our current understanding on the role of this CAF-expressed integrin in these three tumor types.
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleCancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
dc.typeJournal article
dc.creator.authorZeltz, Cedric
dc.creator.authorPrimac, Irina
dc.creator.authorMurugan Erusappan, Pugazendhi
dc.creator.authorAlam, Jahedul
dc.creator.authorNoel, Agnes
dc.creator.authorGullberg, Donald
cristin.unitcode185,53,15,10
cristin.unitnameInstitutt for eksperimentell medisinsk forskning
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1734567
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Seminars in Cancer Biology&rft.volume=&rft.spage=1&rft.date=2019
dc.identifier.jtitleSeminars in Cancer Biology
dc.identifier.volume62
dc.identifier.startpage166
dc.identifier.endpage181
dc.identifier.doihttps://doi.org/10.1016/j.semcancer.2019.08.004
dc.identifier.urnURN:NBN:no-77946
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1044-579X
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74836/5/1-s2.0-S1044579X19300380-main.pdf
dc.type.versionPublishedVersion
dc.relation.projectEC/H2020/316610
dc.relation.projectNFR/223250
dc.relation.projectSIU/PNA-2014/10057


Files in this item

Appears in the following Collection

Hide metadata

Attribution-NonCommercial-NoDerivatives 4.0 International
This item's license is: Attribution-NonCommercial-NoDerivatives 4.0 International