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dc.date.accessioned2020-04-20T09:31:17Z
dc.date.available2020-04-20T09:31:17Z
dc.date.created2019-10-23T12:48:35Z
dc.date.issued2019
dc.identifier.citationTrønnes, Johanne Naper Wood, Mollie Lupattelli, Angela Ystrøm, Eivind Nordeng, Hedvig Marie Egeland . Prenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children. Paediatric and Perinatal Epidemiology. 2019
dc.identifier.urihttp://hdl.handle.net/10852/74637
dc.description.abstractBackground Recent studies have suggested an association between prenatal paracetamol exposure and adverse neurodevelopmental outcomes in children. However, these findings may be confounded by unmeasured factors related to maternal use of paracetamol and child outcomes. Objective To examine the association between duration and timing of prenatal paracetamol exposure on parent‐reported communication skills, behaviour, and temperament in preschool‐aged children, with focus on the role of unmeasured confounding. Methods We used data from the Norwegian Mother and Child Cohort Study. Linear and generalised linear models with inverse probability weights and robust standard errors were used to quantify the association between prenatal paracetamol exposure and continuous and categorical outcomes. Results Of the 32 934 children included in our study, 8374 (25.4%), 4961 (15.1%), and 1791 (5.4%) were prenatally exposed to paracetamol in one, two, and three trimesters, respectively. Children exposed to paracetamol in two trimesters scored lower on shyness compared with unexposed children (β −0.62, 95% confidence interval [CI] −1.05, −0.19). Children exposed to paracetamol in three trimesters had a moderate increased risk of internalising behaviour problems (relative risk (RR) 1.36, 95% CI 1.02, 1.80) and borderline externalising behaviour problems (RR 1.22, 95% CI 0.93, 1.60) compared with unexposed children. Children exposed to paracetamol in 2nd/3rd trimester scored lower on shyness (β −0.32, 95% CI −0.66, 0.02) compared with unexposed children. Sensitivity analyses indicated that unmeasured confounders play an important role and may potentially bias the effect estimates away from the null. Conclusions Timing of exposure and short‐term use of paracetamol during pregnancy do not seem to pose any substantial risk of the outcomes examined. Although we found an association between paracetamol use in multiple trimesters and lower shyness and greater internalising behaviour in preschool‐aged children, we cannot rule out chance or unmeasured confounding as possible explanations for these findings.
dc.languageEN
dc.publisherBlackwell Science Ltd.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePrenatal paracetamol exposure and neurodevelopmental outcomes in preschool-aged children
dc.typeJournal article
dc.creator.authorTrønnes, Johanne Naper
dc.creator.authorWood, Mollie
dc.creator.authorLupattelli, Angela
dc.creator.authorYstrøm, Eivind
dc.creator.authorNordeng, Hedvig Marie Egeland
cristin.unitcode185,15,23,10
cristin.unitnameGalenisk farmasi og samfunnsfarmasi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1739833
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Paediatric and Perinatal Epidemiology&rft.volume=&rft.spage=&rft.date=2019
dc.identifier.jtitlePaediatric and Perinatal Epidemiology
dc.identifier.doihttp://dx.doi.org/10.1111/ppe.12568
dc.identifier.urnURN:NBN:no-77786
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0269-5022
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74637/2/Troennes_2019_Pre.pdf
dc.type.versionPublishedVersion
dc.relation.projectNFR/288083


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