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dc.date.accessioned2020-04-15T19:13:15Z
dc.date.created2019-10-30T13:59:41Z
dc.date.issued2020
dc.identifier.citationSøgaard, Anne-Johanne Magnus, Jeanette H. Bjørnerem, Åshild Holvik, Kristin Ranhoff, Anette Hylen Emaus, Nina Meyer, Haakon E Strand, Bjørn Heine . Grip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995. Osteoporosis International. 2019
dc.identifier.urihttp://hdl.handle.net/10852/74551
dc.description.abstractSummary In 50–79-year-olds who participated in the Tromsø Study (1994–1995), the risk of non-vertebral osteoporotic fractures during 15 years follow-up increased by 22% in men and 9% in women per 1 SD lower grip strength. The strongest association was observed in men aged 50–64 years. Introduction We aimed to explore whether low grip strength was associated with increased risk of non-vertebral osteoporotic fracture in the population-based Tromsø Study 1994–1995. Methods Grip strength (bar) was measured by a Martin Vigorimeter and fractures were retrieved from the X-ray archives at the University Hospital of North Norway between 1994 and 2010. At baseline, weight and height were measured, whereas information on the other covariates were obtained through self-reported questionnaires. Cox regression was used to estimate the hazard ratio (HR) of fracture in age- and gender-specific quintiles of grip-strength, and per 1 SD lower grip strength. Similar analyses were done solely for hip fractures. Adjustments were made for age, height, body mass index (BMI), marital status, education, smoking, physical activity, use of alcohol, self-perceived health, and self-reported diseases. Results In 2891 men and 4002 women aged 50–79 years, 1099 non-vertebral osteoporotic fractures—including 393 hip fractures—were sustained during the median 15 years follow-up. Risk of non-vertebral osteoporotic fracture increased with declining grip strength: hazard ratios per SD decline was 1.22 (95% CI 1.05–1.43) in men and 1.09 (95% CI 1.01–1.18) in women. HR for fracture in lower vs. upper quintile was 1.58 (95% CI 1.02–2.45) in men and 1.28 (95% CI 1.03–1.59) in women. The association was most pronounced in men aged 50–64 years with HR = 3.39 (95% CI 1.76–6.53) in the lower compared to the upper quintile. Conclusions The risk of non-vertebral osteoporotic fracture increased with declining grip-strength in both genders, particularly in men aged 50–64 years.
dc.languageEN
dc.titleGrip strength in men and women aged 50–79 years is associated with non-vertebral osteoporotic fracture during 15 years follow-up: The Tromsø Study 1994–1995
dc.typeJournal article
dc.creator.authorSøgaard, Anne-Johanne
dc.creator.authorMagnus, Jeanette H.
dc.creator.authorBjørnerem, Åshild
dc.creator.authorHolvik, Kristin
dc.creator.authorRanhoff, Anette Hylen
dc.creator.authorEmaus, Nina
dc.creator.authorMeyer, Haakon E
dc.creator.authorStrand, Bjørn Heine
dc.date.embargoenddate2020-10-25
cristin.unitcode185,50,1,0
cristin.unitnameSeksjon for ledelse
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1742301
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Osteoporosis International&rft.volume=&rft.spage=&rft.date=2019
dc.identifier.jtitleOsteoporosis International
dc.identifier.volume31
dc.identifier.issue1
dc.identifier.startpage131
dc.identifier.endpage140
dc.identifier.pagecount10
dc.identifier.doihttps://doi.org/10.1007/s00198-019-05191-4
dc.identifier.urnURN:NBN:no-77674
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn0937-941X
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74551/1/Sogaard_2019_Gri_postprint.pdf
dc.type.versionAcceptedVersion


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