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dc.date.accessioned2020-04-04T18:43:27Z
dc.date.available2020-04-04T18:43:27Z
dc.date.created2019-04-29T16:41:05Z
dc.date.issued2019
dc.identifier.citationSubbannayya, Yashwanth Pinto, Sneha M. Bösl, Korbinian Prasad, T. S. Keshava Kandasamy, Richard Kumaran . Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling. International Journal of Molecular Sciences. 2019, 20(9), 1-22
dc.identifier.urihttp://hdl.handle.net/10852/74380
dc.description.abstractDual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members of the DUSP family with protein kinases is not well understood. Recent multi-omics studies characterizing the transcriptomes and proteomes of immune cells have provided snapshots of molecular mechanisms underlying innate immune response in unprecedented detail. In this study, we focus on deciphering the interplay between members of the DUSP family with protein kinases in immune cells using publicly available omics datasets. Our analysis resulted in the identification of potential DUSP-mediated hub proteins including MAPK7, MAPK8, AURKA, and IGF1R. Furthermore, we analyzed the association of DUSP expression with TLR4 signaling and identified VEGF, FGFR, and SCF-KIT pathway modules to be regulated by the activation of TLR4 signaling. Finally, we identified several important kinases including LRRK2, MAPK8, and cyclin-dependent kinases as potential DUSP-mediated hubs in TLR4 signaling. The findings from this study have the potential to aid in the understanding of DUSP signaling in the context of innate immunity. Further, this will promote the development of therapeutic modalities for disorders with aberrant DUSP signaling.
dc.languageEN
dc.publisherMDPI
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling
dc.typeJournal article
dc.creator.authorSubbannayya, Yashwanth
dc.creator.authorPinto, Sneha M.
dc.creator.authorBösl, Korbinian
dc.creator.authorPrasad, T. S. Keshava
dc.creator.authorKandasamy, Richard Kumaran
cristin.unitcode185,0,0,0
cristin.unitnameUniversitetet i Oslo
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1694617
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Molecular Sciences&rft.volume=20&rft.spage=1&rft.date=2019
dc.identifier.jtitleInternational Journal of Molecular Sciences
dc.identifier.volume20
dc.identifier.issue9
dc.identifier.doihttps://doi.org/10.3390/ijms20092086
dc.identifier.urnURN:NBN:no-77493
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1422-0067
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74380/2/Subbannayya.pdf
dc.type.versionPublishedVersion
cristin.articleid2086
dc.relation.projectNFR/263168
dc.relation.projectNFR/223255
dc.relation.projectNFR/187615


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