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dc.date.accessioned2020-04-04T18:29:29Z
dc.date.available2020-04-04T18:29:29Z
dc.date.created2019-06-17T10:17:36Z
dc.date.issued2019
dc.identifier.citationBenavent, Sigrid Aune de Rodez Nygaard, Gro Owren Nilsen, Kristian Bernhard Etholm, Lars Sowa, Piotr Gustavsen, Marte Wendel Harbo, Hanne Flinstad Drolsum, Liv Laeng, Bruno Kerty, Emilia Celius, Elisabeth Gulowsen . Neurodegenerative interplay of cardiovascular autonomic dysregulation and the retina in early multiple sclerosis. Frontiers in Neurology. 2019, 10:507, 1-9
dc.identifier.urihttp://hdl.handle.net/10852/74373
dc.description.abstractIntroduction: Autonomic nervous system (ANS) symptoms are prevalent in multiple sclerosis (MS) as is neurodegeneration. Our aim was to explore the occurrence of ANS symptoms and retinal neurodegeneration in a newly diagnosed MS population with tools available in a clinical setting. Methods: Forty-three MS patients and 44 healthy controls took part in the study. We employed a bedside cardiovascular ANS test battery together with classical pupillometry, optical coherence tomography (OCT) evaluation of retinal neurodegeneration in eyes without previous optic neuritis (MSNON) and patients' self-report forms on fatigue, orthostatic and ANS symptoms. Results: Half of the patients presented with ANS symptoms and a high level of fatigue. There was a significant difference in ganglion cell layer thickness (mean GCIPL) evaluated by OCT in MSNON compared to healthy control eyes. We found a negative linearity of mean GCIPL on group level with increasing disease duration. Three patients fulfilled the criteria of postural orthostatic tachycardia syndrome (POTS). Conclusion: Our results demonstrate retinal neurodegeneration in MSNON, a high frequency of fatigue and a high prevalence of ANS symptoms in newly diagnosed patients. Whether neurodegeneration precedes ANS dysfunction or vice versa is still open to debate, but as unveiled by the presence of POTS in this MS population, differences in stress-response regulation add to the understanding of variation in onset-time of ANS dysfunction in early MS.
dc.languageEN
dc.publisherFrontiers Media S.A.
dc.relation.ispartofde Rodez Benavent, Sigrid Aune (2020) An ophthalmic acumen: On symptoms and signs in early Multiple Sclerosis. Doctoral thesis http://hdl.handle.net/10852/81343
dc.relation.urihttp://hdl.handle.net/10852/81343
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleNeurodegenerative interplay of cardiovascular autonomic dysregulation and the retina in early multiple sclerosis
dc.typeJournal article
dc.creator.authorBenavent, Sigrid Aune de Rodez
dc.creator.authorNygaard, Gro Owren
dc.creator.authorNilsen, Kristian Bernhard
dc.creator.authorEtholm, Lars
dc.creator.authorSowa, Piotr
dc.creator.authorGustavsen, Marte Wendel
dc.creator.authorHarbo, Hanne Flinstad
dc.creator.authorDrolsum, Liv
dc.creator.authorLaeng, Bruno
dc.creator.authorKerty, Emilia
dc.creator.authorCelius, Elisabeth Gulowsen
cristin.unitcode185,53,42,13
cristin.unitnameNevrologisk avdeling
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin1705303
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers in Neurology&rft.volume=10:507&rft.spage=1&rft.date=2019
dc.identifier.jtitleFrontiers in Neurology
dc.identifier.volume10
dc.identifier.doihttps://doi.org/10.3389/fneur.2019.00507
dc.identifier.urnURN:NBN:no-77475
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1664-2295
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/74373/1/Benavent.pdf
dc.type.versionPublishedVersion
cristin.articleid507


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