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dc.date.accessioned2020-02-27T15:30:02Z
dc.date.available2020-02-27T15:30:02Z
dc.date.created2019-01-25T13:07:17Z
dc.date.issued2018
dc.identifier.citationHalaas, Nathalie Bodd Blennow, Kaj Idland, Ane-Victoria Wyller, Torgeir Bruun Ræder, Johan Frihagen, Frede Jon Staff, Anne Cathrine Zetterberg, Henrik Watne, Leiv . Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium. Dementia and Geriatric Cognitive Disorders. 2018, 46(5-6), 346-357
dc.identifier.urihttp://hdl.handle.net/10852/73376
dc.description.abstractBackground: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury. Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults under-going elective surgery. Delirium was diagnosed with the Confusion Assessment Method. Re-sults: Median serum NFL (pg/mL) was elevated in delirium in hip fracture patients (94 vs. 54 pre- and 135 vs. 92 postoperatively, both p < 0.001). Median CSF NFL tended to be higher in hip fracture patients with delirium (1,804 vs. 1,636, p = 0.074). Serum and CSF NFL were posi-tively correlated (ρ = 0.56, p < 0.001). Conclusion: Our findings support an association be-tween neuroaxonal injury and delirium. The correlation between serum and CSF NFL supports the use of NFL as a blood biomarker in future delirium studies.
dc.languageEN
dc.publisherKarger
dc.titleNeurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium
dc.typeJournal article
dc.creator.authorHalaas, Nathalie Bodd
dc.creator.authorBlennow, Kaj
dc.creator.authorIdland, Ane-Victoria
dc.creator.authorWyller, Torgeir Bruun
dc.creator.authorRæder, Johan
dc.creator.authorFrihagen, Frede Jon
dc.creator.authorStaff, Anne Cathrine
dc.creator.authorZetterberg, Henrik
dc.creator.authorWatne, Leiv
cristin.unitcode185,17,5,0
cristin.unitnamePsykologisk institutt
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1
dc.identifier.cristin1665119
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Dementia and Geriatric Cognitive Disorders&rft.volume=46&rft.spage=346&rft.date=2018
dc.identifier.jtitleDementia and Geriatric Cognitive Disorders
dc.identifier.volume46
dc.identifier.issue5-6
dc.identifier.startpage346
dc.identifier.endpage357
dc.identifier.doihttps://doi.org/10.1159/000494754
dc.identifier.urnURN:NBN:no-76512
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1420-8008
dc.identifier.fulltextFulltext https://www.duo.uio.no/bitstream/handle/10852/73376/2/Revised_NEUROFILAMENT%2BLIGHT%2BIN%2BSERUM%2BAND%2BCEREBROSPINAL%2BFLUID%2BIN%2BHIP%2BFRACTURE%2BPATIENTS%2BWITH%2BDELIRIUM.pdf
dc.type.versionAcceptedVersion


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